Longitudinal Variations of -Induced IFN-γ Responses in HIV-Negative Pregnant Women Exposed to Tuberculosis.

Introduction: Pregnancy triggers an alteration of the immune functions and increases the risk of developing the active tuberculosis (TB) symptoms in exposed women. The effect of pregnancy on the specific immune responses used for most of the TB immunodiagnostic assays is not well documented. Here we investigated the changes in the -specific IFN-γ production in age-matched pregnant and non-pregnant women according to their TB exposition status.