Publications by authors named "Arima K"
Article Synopsis
- In April 2020, new guidelines by the Japanese Circulation Society recommended shorter dual antiplatelet therapy (DAPT) for high bleeding risk patients, prompting a study in June 2020 involving 1,136 patients who had undergone percutaneous coronary intervention (PCI).
- The study found that 55.2% of patients received planned short DAPT (less than 3 months), resulting in a significantly shorter average DAPT duration compared to those on standard therapy, but similar rates of major adverse cardiovascular events and bleeding complications across both groups.
- Key factors predicting adverse events included age 75 or older, certain health conditions like severe chronic kidney disease, and low hemoglobin levels, indicating that despite the shorter therapy,
Aims: Direct oral anticoagulants (DOACs) are used to treat venous thromboembolism (VTE). However, their impact on thrombus regression and the clinical outcomes after 2-week post-therapy computed tomography (CT) monitoring remains unexplored. This study aimed to elucidate the characteristics of patients with VTE treated with individual DOACs, assess the incidence of clinical events, and evaluate their impact on pulmonary artery thrombus regression.
View Article and Find Full Text PDFCirculating CD34-positive cell count is inversely associated with height loss. It acts as an indicator of endothelial repair activity. In conjunction with CD34-positive cells, platelets contribute to endothelial repair.
View Article and Find Full Text PDFWe sought to clarify the musculoskeletal ultrasound (MSUS) findings and serum concentrations of cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica (GC-R PMR). Patients with PMR admitted to Nagasaki University Hospital ( = 41) were enrolled. MSUS of both shoulder joints was performed in 36 patients.
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- - This study investigates how solubilization carriers, like cyclodextrin, impact the absorption of poorly soluble drugs, using dexamethasone as a model drug, by examining the solubility-permeability interplay.
- - The research includes various testing methods, both in vitro (laboratory experiments) and in vivo (animal studies), comparing results from permeation through synthetic membranes to actual oral administration in mice and dogs.
- - While in vitro studies showed significant interactions reducing drug absorption, in vivo findings revealed minimal effects, suggesting that real-life biological factors, such as dilution and drug interaction in the gastrointestinal tract, limit the relevance of lab results for predicting true drug absorption.
Comparative biochemical characterization of pufferfish saxitoxin and tetrodotoxin-binding protein (PSTBP) homologs in the plasma from four Takifugu species: Conservation of heat-stable PSTBP orthologs having three and two tandemly repeated lipocalin domains in genus Takifugu.
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
Article Synopsis
- The study examines the relationship between the characteristics of pufferfish PSTBP proteoforms and their thermal stability across four Takifugu species.
- The researchers used methods like Western blot analysis and LC-MS/MS to confirm the heat-tolerance of these proteins, especially in T. rubripes.
- Findings indicate that heat-stable PSTBP proteoforms are genetically conserved within the genus, enhancing our understanding of toxin transmission in seafood and its associated risks.
Article Synopsis
- Prurigo nodularis (PN) is a chronic skin condition characterized by itchy nodules, and its unclear causes complicate effective treatment and diagnosis, especially in Japan.
- A survey of 117 Japanese dermatologists revealed that they typically diagnose PN based on clinical signs and patient interviews, primarily assess severity by counting itchy nodules, and commonly use topical corticosteroids and antihistamines for treatment.
- Many dermatologists expressed dissatisfaction with the current treatment options for severe PN, indicating a significant need for improved medications and diagnostic methods.
Aim: To clarify the association between genetic factors related to angiogenesis and feeling of incomplete bladder emptying among older community-dwelling individuals.
Method: A cross-sectional study of 1762 (607 men and 1155 women) older Japanese individuals aged 60-79 years with data on rs3025020 was conducted, because vascular endothelial growth factor (VEGF), which contributes to the progression of angiogenesis, has been reported to be positively associated with the minor allele (T) of polymorphism rs3025020.
Results: In the study population, 155 (103 men and 52 women) had feeling of incomplete bladder emptying.
The activation of yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) has been implicated in both regeneration and tumorigenesis, thus representing a double-edged sword in tissue homeostasis. However, how the activity of YAP1/TAZ is regulated or what leads to its dysregulation in these processes remains unknown. To explore the upstream stimuli modulating the cellular activity of YAP1/TAZ, we developed a highly sensitive YAP1/TAZ/TEAD-responsive DNA element (YRE) and incorporated it into a lentivirus-based reporter cell system to allow for sensitive and specific monitoring of the endogenous activity of YAP1/TAZ in terms of luciferase activity in vitro and Venus fluorescence in vivo.
View Article and Find Full Text PDFBackground & Aims: Epidemiologic evidence for dietary influence on colorectal cancer (CRC) risk through the gut microbiome remains limited.
Methods: Leveraging 307 men and 212 women with stool metagenomes and dietary data, we characterized and validated a sex-specific dietary pattern associated with the CRC-related gut microbial signature (CRC Microbial Dietary Score [CMDS]). We evaluated the associations of CMDS with CRC risk according to Fusobacterium nucleatum, pksEscherichia coli, and enterotoxigenic Bacteroides fragilis status in tumor tissue using Cox proportional hazards regression in the Health Professionals Follow-Up Study (1986-2018), Nurses' Health Study (1984-2020), and Nurses' Health Study II (1991-2019).
[Purpose] A method for evaluating integrated interpretation skills, which is an important educational goal in clinical practice, is yet to be established. This study examined the interrater reliability of a problem-solving model that was developed as a novel assessment method. [Participants and Methods] Three students created problem-solving models using fictitious case data.
View Article and Find Full Text PDFEvidence indicates that combinations of anti-EGFR antibodies and KRAS p.G12C (c.34G>T) inhibitors can be an effective treatment strategy for advanced colorectal cancer.
View Article and Find Full Text PDFAlthough fast eating speed has been associated with cardiovascular risk factors, no studies have reported an association between fast eating speed and atherosclerosis as evaluated by carotid intima-media thickness (CIMT). Rapid glucose ingestion is known to cause glucose spikes, which may accelerate atherogenesis and increase levels of growth differentiation factor 15 (GDF-15). Therefore, GDF-15 levels may influence the association between fast eating speed and atherosclerosis.
View Article and Find Full Text PDFCarbon-based nanopowders have been used as ionization materials for laser desorption ionization-mass spectrometry (LDI-MS) and are very efficient at detection in low / regions. In this study, we aimed to develop a new sheet-type graphite material that possessed a randomly grooved nanostructured surface consisting of developed sp-conjugated atomic carbon to facilitate the desorption/ionization of small compounds in LDI-MS. The graphite sheet exhibited higher UV absorption and provided higher ionization efficiency and survival yield in the LDI-MS detection of a thermometer ion, 4-chloro-benzopyridinium, than those of highly oriented graphite plates.
View Article and Find Full Text PDFChronic spontaneous urticaria (CSU), characterized by the recurrence of pruritic hives and/or angioedema for >6 weeks with no identifiable trigger, has a negative impact on health-related quality of life (HRQoL). The objective of this web-based cross-sectional study was to evaluate disease control, disease burden, and treatment satisfaction in Japanese adults with CSU using the Urticaria Control Test (UCT), HRQoL outcomes, and the Treatment Satisfaction Questionnaire for Medication-9 items (TSQM-9). In total, 529 adults were included in the analysis (59.
View Article and Find Full Text PDFBackground: We investigated the efficacy and safety of dupilumab in Japanese patients aged ≥6 months to <18 years old with moderate-to-severe atopic dermatitis not adequately controlled with existing therapies.
Methods: In this randomized, double-blind, phase 3 study, patients received dupilumab (n = 30) or placebo (n = 32) with concomitant topical corticosteroids for 16 weeks, then all patients received dupilumab from 16 to 52 weeks. The primary endpoint was the proportion of patients with ≥75% improvement in Eczema Area and Severity Index (EASI) score from baseline (EASI-75) to Week 16.
Unlabelled: This 5-year longitudinal study investigated the relationship between depressive symptoms and fracture risk in a large Japanese cohort. Depressive symptoms were a significant risk factor for hip fractures in women.
Purpose: A relationship between depressive symptoms and fractures has not been clearly demonstrated.
The magnitude of the effect of human T-lymphotropic virus 1 (HTLV-1) infection on uveitis remains unclear. We conducted a cross-sectional study in a highly endemic area of HTLV-1 in Japan. The study included 4265 residents (men, 39.
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- - The study aimed to investigate whether having an appendectomy reduces the long-term risk of colorectal cancer, particularly for tumors associated with the bacterial species Fusobacterium nucleatum, which is linked to colorectal tumor development.
- - Using data from extensive cohort studies, researchers found that 2811 cases of colorectal cancer were recorded, with appendectomy appearing to lower the incidence of F. nucleatum-positive cancers (hazard ratio of 0.53) but not F. nucleatum-negative cancers (hazard ratio of 0.98).
- - The findings suggest that while appendectomy may reduce the risk of developing certain types of colorectal cancer (specifically F. nucleatum-positive ones), it does not significantly impact the risk for other types,
Article Synopsis
- A study was conducted to investigate the relationship between various beverage types (sugary drinks, carbonated beverages, vegetable and fruit juices, sweetened and black coffee, and green tea) and depression among individuals in an Asian population, with a focus on the years 2011-2016 and a five-year follow-up.
- The research included 94,873 participants, out of which 80,497 completed the follow-up, revealing that high consumption of sugary drinks, carbonated beverages, vegetable juice, and sweetened coffee was associated with increased depression rates, while black coffee consumption appeared to have a protective effect.
- The study utilized advanced statistical methods to ensure robust findings, indicating no significant differences based on participants' sex,
Atherosclerosis and height loss are each reportedly associated with cardiovascular disease. However, no studies have found an association between atherosclerosis and height loss. A retrospective study of 2435 individuals aged 60-89 years who underwent annual health check-ups was conducted.
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- Researchers created a new method using graphite carbon black (GCB) combined with laser desorption ionization mass spectrometry (LDI-MS) to analyze taste and odor compounds in food.
- They tested this method on various soy sauces and successfully differentiated products based on their country of origin (Japan, China, India) without complicated sample preparation.
- The analysis provided clear chemical patterns and distinct mass spectrometry peaks that correlated with the quantity of compounds in the soy sauces, establishing GCB-LDI-MS as an efficient tool for food quality assessment.
Coronavirus disease 2019 (COVID-19) was extraordinarily harmful, with high rates of infection and hospitalization. This study aimed to evaluate the impact of COVID-19 vaccination status and other factors on hospitalization and disease severity, using data from Nagasaki Prefecture, Japan. Confirmed cases of COVID-19 infection with vaccination status were included and the differences in characteristics between different vaccination statuses, hospitalization or not, and patients with varying levels of disease severity were analyzed.
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- The study analyzes mortality rates in patients who achieved sustained virological response (SVR) after receiving interferon-free direct-acting antiviral (IFN-free DAA) therapy, emphasizing the significance of non-liver-related deaths.
- Three cohorts were examined: those without advanced fibrosis or prior hepatocellular carcinoma (HCC), those with advanced fibrosis but no prior HCC, and those with a history of HCC after curative treatment.
- Findings indicated that while both non-HCC cohorts had comparable mortality rates to the general population, the cohort with a history of HCC had higher overall mortality, highlighting the need to address non-liver-related health issues in all SVR patients.