Ringo: Interactive Graph Analytics on Big-Memory Machines.

We present Ringo, a system for analysis of large graphs. Graphs provide a way to represent and analyze systems of interacting objects (people, proteins, webpages) with edges between the objects denoting interactions (friendships, physical interactions, links). Mining graphs provides valuable insights about individual objects as well as the relationships among them.

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.

Engineered protein pores have several potential applications in biotechnology: as sensor elements in stochastic detection and ultrarapid DNA sequencing, as nanoreactors to observe single-molecule chemistry, and in the construction of nano- and micro-devices. One important class of pores contains molecular adapters, which provide internal binding sites for small molecules. Mutants of the alpha-hemolysin (alphaHL) pore that bind the adapter beta-cyclodextrin (betaCD) approximately 10(4) times more tightly than the wild type have been obtained.

Pentapeptide based organogels: the role of adjacently located phenylalanine residues in gel formation.

A terminally protected self-assembling pentapeptide Boc-Leu(1)-Val(2)-Phe(3)-Phe(4)-Ala(5)-OMe 1 bearing sequence similarity with Aβ17-21 (the fragment 17-21 of the amyloid β-peptide Aβ42) forms thermoreversible transparent gels in various organic solvents including benzene, toluene, m-xylene and 1,2-dichlorobenzene. A series of its variants have been synthesized in order to study the role of adjacently located phenylalanine residues and the protecting groups for gelation in different organic solvents. Replacement of any of the Phe residues of the Phe-Phe segment with any other hydrophobic α-amino acid residue drastically changes the gel forming properties indicating that both Phe residues have an important role in gel formation.

Histopathological study of conjunctival lesions.

Lesions of conjunctiva comprise a varied spectrum of conditions. A total of 50 patients, 34 males and 16 females, with lesions in conjunctiva were subjected to study. Histopathological examination of the biopsied specimens from the lesions was done using haematoxylin and eosin (H&E) stain and other special stains when needed.

Bilateral scleromalacia in a case of congenital erythropoietic porphyria.

A 25-year-old woman presented with gradual dimness of vision in the left eye with history of recurrent cutaneous bullae, photosensitivity and passage of red coloured urine. Examination revealed cataract and high intra-ocular pressure in left eye and symmetrical areas of scleral thinning in both eyes. Systemic features of the patient pointed towards congenital erythropoietic porphyria, which was established by laboratory investigations.

Childhood malignancies at BS Medical College: a ten year study.

A retrospective study of malignant diseases of childhood was carried out at B. S. Medical College, Bankura, W.

First crystallographic signature of an acyclic peptide nanorod: molecular mechanism of nanorod formation by a self-assembled tetrapeptide.

A terminally protected acyclic tetrapeptide Boc-Aib-Val-Aib-beta-Ala-OMe 1 (Aib: alpha-aminoisobutyric acid, beta-Ala: beta-Alanine) self-assembles into a continuous hydrogen-bonded supramolecular helix with an average diameter of 10 A (1 nm) starting from a double bend molecular conformation in crystals and further self-assembly of this supramolecular architecture leads to the formation of polydisperse nanorods of diameters 10-40 nm.