Steering diffusion selectivity of chemical isomers within aligned nanochannels of metal-organic framework thin film.

The movement of molecules (i.e. diffusion) within angstrom-scale pores of porous materials such as metal-organic frameworks (MOFs) and zeolites is influenced by multiple complex factors that can be challenging to assess and manipulate.

Total Chemical Synthesis of the SARS-CoV-2 Spike Receptor-Binding Domain.

SARS-CoV-2 and its global spread have created an unprecedented public health crisis. The spike protein of SARS-CoV-2 has gained significant attention due to its crucial role in viral entry into host cells and its potential as both a prophylactic and a target for therapeutic interventions. Herein, we report the first successful total synthesis of the SARS-CoV-2 spike protein receptor binding domain (RBD), highlighting the key challenges and the strategies employed to overcome them.

Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease.

This article highlights recent pioneering work by Günther et al. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (M ). The antiviral activity of the most potent drugs is discussed along with their binding mode to M as observed through X-ray crystallographic screening.

Trisubstituted geminal diazaalkene derived transient 1,2-carbodications.

The coulombic repulsion between two adjacent cation centres of 1,2-carbodications is known to decrease with π- and/or n-donor substituents by a positive charge delocalization. Here we report the delocalization of the positive charge of transient 1,2-carbodications having one H-substituent by an intramolecular base-coordination. N-heterocyclic olefin (NHO) derived 2-pyrrolidinyl appended trisubstituted geminal diazaalkenes were used for the generation of transient 1,2-carbodications through a 2-e chemical oxidation process.

Activation of Aromatic C-F Bonds by a N-Heterocyclic Olefin (NHO).

A N-heterocyclic olefin (NHO), a terminal alkene selectively activates aromatic C-F bonds without the need of any additional catalyst. As a result, a straightforward methodology was developed for the formation of different fluoroaryl-substituted alkenes in which the central carbon-carbon double bond is in a twisted geometry.