Prospects of e-Coaching as a Platform for Empowering Families of Person With Mental Disorder: A Qualitative Study.

Introduction: In all countries, the burden of mental disorders (MDs) spans the entire life course. Smartphones are currently widely used by families with a history of MD looking for the required mental health information. The use of digital media is an alternative to improving the ability of families to care for person with MD at home.

A Modified EMD Technique for Broken Rotor Bar Fault Detection in Induction Machines.

Induction machines (IMs) are commonly used in various industrial sectors. It is essential to recognize IM defects at their earliest stage so as to prevent machine performance degradation and improve production quality and safety. This work will focus on IM broken rotor bar (BRB) fault detection, as BRB fault could generate extra heating, vibration, acoustic noise, or even sparks in IMs.

BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes.

T cell co-inhibitory immune checkpoints, such as PD-1 or BTLA, are bona fide targets in cancer therapy. We used a human T cell reporter line to measure transcriptomic changes mediated by PD-1- and BTLA-induced signaling. T cell receptor (TCR)-complex stimulation resulted in the upregulation of a large number of genes but also in repression of a similar number of genes.

Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity.

Prions can exist as different strains that consist of conformational variants of the misfolded, pathogenic prion protein isoform PrPSc. Defined by stably transmissible biological and biochemical properties, strains have been identified in a spectrum of prion diseases, including chronic wasting disease (CWD) of wild and farmed cervids. CWD is highly contagious and spreads via direct and indirect transmission involving extraneural sites of infection, peripheral replication and neuroinvasion of prions.

Norwegian moose CWD induces clinical disease and neuroinvasion in gene-targeted mice expressing cervid S138N prion protein.

Chronic wasting disease (CWD) is a prion disease affecting deer, elk and moose in North America and reindeer, moose and red deer in Northern Europe. Pathogenesis is driven by the accumulation of PrPSc, a pathological form of the host's cellular prion protein (PrPC), in the brain. CWD is contagious among North American cervids and Norwegian reindeer, with prions commonly found in lymphatic tissue.

A novel subsurface slopes hazardous mapping with engineering geologic and geophysical characterizations.

Engineering geological characterizations, and geophysical mapping of subsurface structures to monitor some susceptible infrastructural facilities to hazardous slopes for effectiveness, safety to lives and properties, in addition to policy management for sustainable development. Novel integrated engineering geology, geoelectrical resistivity (ER), and borehole data analysis, to characterize subsurface for slope instability, determining critical zones prone to hazardous slopes in Peninsular Malaysian (PM), east coast areas was focused on. Engineering Laboratory soil investigations using disturbed and undisturbed samples collected to obtain firsthand information on the subsurface soils, and rocks physical properties, integrated with ER data to obtain subsurface geoelectric profiles.

Silver nanoparticles-based localized surface plasmon resonance biosensor for Escherichia coli detection.

Escherichia coli (E. coli) bacteria with varying solution concentrations have been successfully detected using silver nanoparticles (Ag NPs)-based localized surface plasmon resonance (LSPR) biosensors. The Ag NPs were effectively synthesized by a chemical method using trisodium citrate with L-Histidine (L-His) and deposited on the surface of Au thin film-coated half-cylinder BK-7 prisms.

Propagation of PrP in mice reveals impact of aggregate composition on prion disease pathogenesis.

Infectious prions consist of PrP, a misfolded, aggregation-prone isoform of the host's prion protein. PrP assemblies encode distinct biochemical and biological properties. They harbor a specific profile of PrP species, from small oligomers to fibrils in different ratios, where the highest infectivity aligns with oligomeric particles.

Assessing the Effectiveness of an E-Coaching Intervention in Improving Family Support for Individuals with Mental Disorders: A Quasi-Experimental Approach.

Background: The increasing number of mental disorders (MDs) requires government, social, and family attention. The purpose of this study was to determine the effectiveness of an e-coaching empowerment application in improving families' abilities to care for individuals with mental disorders (MDs).

Methods: A quasi-experimental design was used for this study.

Recent advances in advanced oxidation processes (AOPs) for the treatment of nitro- and alkyl-phenolic compounds.

The presence of phenolic compounds in the aquatic environment has posed severe risks due to their toxicity. Among the phenolic families, nitro- and alkyl-phenolic compounds have been categorized as precedence contaminants by the United States Environmental Protection Agency (US EPA). Therefore, efficient treatment methods for wastewater containing nitro- and alkyl-phenolic compounds are urgently needed.

Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion.

Prions are proteinaceous infectious particles that replicate by structural conversion of the host-encoded cellular prion protein (PrP), causing fatal neurodegenerative diseases in mammals. Species-specific amino acid substitutions (AAS) arising from single nucleotide polymorphisms within the prion protein gene () modulate prion disease pathogenesis, and, in several instances, reduce susceptibility of homo- or heterozygous AAS carriers to prion infection. However, a mechanistic understanding of their protective effects against clinical disease is missing.

COVID-19 knowledge, attitude, practices, and associated factors among Bangladeshi food handlers from various food industries.

Background And Objectives: It is believed that preventive safety measures are the most effective way to avoid the COVID-19. The adherence of workers to these measures is largely determined by their knowledge, attitude, and practices (KAP). Because they are in close proximity to consumable items, workers in the food industry must be especially vigilant during this period.

Hydrogeophysical modeling of the groundwater aquifer units under climate variability in parts of Peninsular Malaysia: A case study of the climate-water nexus approach to sustainability.

Understanding of the climate-water nexus for sustainability, required good knowledge of the climate effects on groundwater aquifer units, particularly in rural communities. The studies were achieved using RES2-D modelling of the subsurface structures at the study site. Geophysical exploration with the application of 2-D Electrical Resistivity Imaging (ERI), combined with Induced Polarization (IP) method, were carried out to identify groundwater aquifers during extreme weather at , Peninsular Malaysia.

Crashworthiness Assessment of Carbon/Glass Epoxy Hybrid Composite Tubes Subjected to Axial Loads.

The crashworthiness of composite tubes is widely examined for various types of FRP composites. However, the use of hybrid composites potentially enhances the material characteristics under impact loading. In this regard, this study used a combination of unidirectional glass-carbon fibre reinforced epoxy resin as the hybrid composite tube fabricated by the pultrusion method.

COVID-19 knowledge, attitude, and practices among the Rohingya refugees in Cox's Bazar, Bangladesh.

Objectives: The Rohingya refugee population in Bangladesh has become more vulnerable to COVID-19 because of their living and environmental conditions. The aim of the study was to represent an assessment of the Rohingya people's COVID-19-related knowledge, attitude, and practices (KAP) at eight refugee camps in Cox's Bazar.

Study Design: Cross-sectional study.

Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD.

Prions cause infectious and fatal neurodegenerative diseases in mammals. Chronic wasting disease (CWD), a prion disease of cervids, spreads efficiently among wild and farmed animals. Potential transmission to humans of CWD is a growing concern due to its increasing prevalence.

Posttraumatic epilepsy: A single institution case series in Indonesia.

Background: Posttraumatic epilepsy (PTE) is a debilitating sequelae following traumatic brain injury (TBI). Risk of developing PTE is higher in the first 6 months following head trauma and remains increased for 10 years. Many cases of PTE developed into drug-resistant epilepsy in which need surgical treatment.

Skull Base Approaches for Tuberculum Sellae Meningiomas: Institutional Experience in a Series of 34 Patients.

(1) Background: The aim of the present study was to evaluate our institutional outcome in tuberculum sellae meningioma (TSM) patients treated microsurgically using multiple skull base approaches, including a transcranial approach and an extended endonasal transsphenoidal approach. (2) Materials and Methods: This is a retrospective study that includes 34 patients with TSM. The study aimed to observe the efficacy of the different common approaches used by a single neurosurgeon.

Gene-Edited Cell Models to Study Chronic Wasting Disease.

Prion diseases are fatal infectious neurodegenerative disorders affecting both humans and animals. They are caused by the misfolded isoform of the cellular prion protein (PrP), PrP, and currently no options exist to prevent or cure prion diseases. Chronic wasting disease (CWD) in deer, elk and other cervids is considered the most contagious prion disease, with extensive shedding of infectivity into the environment.

Postoperative Evaluation of the Quality of Life, Depression, and Anxiety of Temporal Lobe Epilepsy Cohort: A Single Institute Experience in Indonesia.

Besides seizure control, quality of life (QoL) should be considered as an equally important outcome for epilepsy surgery service providers. The paucity of QoL reports from developing countries has enlarged the representation gap between wealthy countries and countries with fewer resources. In this study, we evaluated postoperative QoL in the Indonesian drug-resistant epilepsy cohort where the epilepsy surgery service faces limited resource availability.

DNA isolation success rates from dried and fresh wood samples of selected 20 tropical wood tree species for possible consideration in forensic forestry.

The successful isolation of DNA (Deoxyribonucleic Acid) is essential for the investigation process of forestry molecular genetics. Samples used are usually retrieved either from soft or juvenile plant organs because of their excellent DNA source. However, in certain cases, aforesaid samples are hard to obtain, as for forensic purposes.

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.

Chronic wasting disease (CWD) is a prion disease affecting cervids. Polymorphisms in the prion protein gene can result in extended survival of CWD-infected animals. However, the impact of polymorphisms on cellular prion protein (PrPC) and prion properties is less understood.

A review on chitosan and chitosan-based bionanocomposites: Promising material for combatting global issues and its applications.

Over the last few years, several attempts have been made to replace petrochemical products with renewable and biodegradable components. The most challenging part of this approach is to obtain bio-based materials with properties and functions equivalent to those of synthetic products. Various naturally occurring polymers such as starch, collagen, alginate, cellulose, and chitin represent attractive candidates as they could reduce dependence on synthetic products and consequently positively impact the environment.