Biomarkers.

Background: The amplitude of resting-state electroencephalographic (rsEEG) rhythms is a promising neurophysiological biomarker to investigate the abnormalities of oscillatory neurophysiological thalamocortical mechanisms related to the general cortical arousal and vigilance in wakefulness in patients with dementia due to neurodegenerative diseases as Alzheimer's disease (ADD), Parkinson's disease (PDD) and Lewy Body disease (DLB). Here, we tested the hypothesis that the reactivity of posterior rsEEG alpha (about 8-12 Hz) rhythms during the transition from eyes-closed to -open condition may be lower in PDD patients than in DLB patients.

Methods: A Eurasian database provided clinical-demographic-rsEEG datasets in 35 ADD patients, 65 PDD patients, 30 DLB patients, and 25 matched cognitively unimpaired (Healthy) persons.

Biomarkers.

Background: Early-onset Alzheimer's disease (EOAD), manifesting before age 65, demands nuanced diagnostic approaches. FDG18-PET unveils metabolic insights, the MRI scale captures structural changes, and ACE-R assesses cognitive impairment details. A holistic evaluation enhances diagnostic precision and enriches our understanding of cognitive decline in early-onset presentations.

Biomarkers.

Background: Vigilance and sleep disturbances in Alzheimer's and related diseases, even at the stage of mild cognitive impairment (MCI), have been extensively documented, showing abnormal daytime naps and alterations in the sleep-wake cycle. However, the EEG correlates of the transition from wakefulness to light sleep have not yet been compared between MCI patients due to Alzheimer's vs. other neurodegenerative diseases.

Biomarkers.

Background: Patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) are characterized by abnormalities in resting-state electroencephalographic (rsEEG) rhythms as measures of brain neural synchronization dysfunction (Babiloni et al., PMID: 33860614). Here, we tested the two following hypotheses that those rsEEG abnormalities: (i) may be higher in ADMCI patients than in patients with MCI not due to AD (noADMCI); and (ii) may be related to the AD diagnostic amyloid-tau biomarkers derived from cerebrospinal fluid (CSF).

Biomarkers.

Background: Mild cognitive impairment (MCI) is viewed as a transitional stage between normal aging and Alzheimer's disease (AD), serving as a pathological precursor to AD. Longitudinal studies indicate an annual conversion rate from MCI to AD of 10-15%. Our previous studies have shown decreased coherence values in visual event-related slow frequency bands including theta frequency.

Biomarkers.

Background: Early-onset Alzheimer's disease (EOAD), distinct from late-onset cases, tends to present with atypical cognitive decline, such as, progressive aphasia, apraxia, visuospatial and comportmental impairments,. This study aims to investigate correlations between clinical presentation and PET imaging findings in EOAD patients.

Method: A retrospective analysis was conducted on CSF confirmed EOAD patients.

Alzheimer's Imaging Consortium.

Background: Early-onset Alzheimer's disease (EOAD), distinct from late-onset cases, tends to present with atypical cognitive decline, such as, progressive aphasia, apraxia, visuospatial and comportmental impairments,. This study aims to investigate correlations between clinical presentation and PET imaging findings in EOAD patients.

Method: A retrospective analysis was conducted on CSF confirmed EOAD patients.

Alzheimer's Imaging Consortium.

Background: Early-onset Alzheimer's disease (EOAD), manifesting before age 65, demands nuanced diagnostic approaches. FDG18-PET unveils metabolic insights, the MRI scale captures structural changes, and ACE-R assesses cognitive impairment details. A holistic evaluation enhances diagnostic precision and enriches our understanding of cognitive decline in early-onset presentations.

Radiological Perspectives in Congenital Sensorineural Hearing Loss: Insights from Cochlear Implant Candidates.

Congenital hearing loss is a significant health concern, with diverse etiologies encompassing cochlear and cochleovestibular pathologies. Preoperative radiological evaluation in cochlear implant candidates is pivotal for treatment planning. We aim to elucidate the spectrum of radiological findings in patients with congenital hearing loss undergoing cochlear implant assessment.

Employer Perspective on Pain Fellowship Education: A Survey to Understand the Current State of Pain Medicine Training.

Background: Pain medicine care has expanded to encompass a wider range of conditions, necessitating updated education and training for pain specialists to utilize emerging technologies effectively. A national survey was conducted through several verified Pain organizations regarding pain physician employers' perspectives on pain medicine fellowship training and education. The survey aimed to gather insights from a diverse range of geographic locations, practice types (academic and private practice), and practice settings.

Prognostic Significance of Preoperative NLR or PLR and PASS Score Combinations in Pheochromocytoma and Paraganglioma.

Context: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have recently emerged in assessing pheochromocytomas and paragangliomas (PPGLs). However, their combined use with PASS scale has not yet been explored.

Objective: Our goal was to investigate the prognostic values of NLR and PLR and incorporate the PASS score into our analysis.

Microglia-like cells from patient monocytes demonstrate increased phagocytic activity in probable Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by the accumulation of amyloid plaques, phosphorylated tau tangles and microglia toxicity, resulting in neuronal death and cognitive decline. Since microglia are recognized as one of the key players in the disease, it is crucial to understand how microglia operate in disease conditions and incorporate them into models. The studies on human microglia functions are thought to reflect the post-symptomatic stage of the disease.

Adrenal PEComa Treated by Surgical Resection and Postoperative Radiotherapy: A Case Report.

BACKGROUND Perivascular epitheloid cell neoplasm (PEComa) is a rare mesenchymal tumor that is evaluated in the same tumor family as angiomyolipoma, sugar cell tumor of the lung, and lymphangioleiomyomatosis. Immunohistochemically, the disease can express melanocytic and myogenic markers, such as HMB45, HMSA1, MelanA/Mart1, and actin. The disease can be seen in almost every organ, especially the uterus and retroperitoneum.

Design and use of assistant robotic arm in endoscopic transnasal surgery.

Objective: This study aimed to develop a robotic system with autonomous functionality for holding and manipulating the endoscope in endoscopic endonasal surgery. A cost-effective prototype was created with the goal of using robotic assistance and achieving a more efficient learning curve for endoscopic surgery.

Methods: A Stewart platform-based endoscope holder and positioner robotic system, developed by the Mechatronics Engineering Department of Kocaeli University, was used in conjunction with 3D Slicer and Plus Toolkit open-source health technology software.

MycoTWIN Working Group Discussion: A Multi-Actor Perspective on Future Research Directions for Mycotoxins and Toxigenic Fungi Along the Food and Feed Chain.

Mycotoxin research is facing unprecedented challenges, starting from the urgent need to cope with the consequences of climate change, the global shortage of grain due to unstable political scenarios, and the major transformation of the supply chains after the COVID-19 pandemic. In this scenario, the mycotoxin contamination of human and animal foods is still unavoidable, thus representing a major challenge to global food security. Next to this, the shift to sustainable and circular food production might be accompanied by an increase in food safety issues involving mycotoxins, e.

The relationship between single leg balance and proprioception of the knee joint in individuals with non-specific chronic back pain.

Background: Proprioceptive information from the hips, knees, and ankles as well as joint coordination are important for maintaining and controlling balance. Regional receptors in the muscles, joints, skin, and tendons as well as proprioception in the knee joint provide the necessary joint activity and stability. Pain may occur with a decreased sense of balance and proprioception.

The journey of MEFV heterozygous children: with or without colchicine.

To investigate the rate of colchicine use in the longitudinal follow-up of familial Mediterranean fever (FMF) carriers and identify variables that could predict the necessity of colchicine treatment in this group. The study was conducted in 9 pediatric rheumatology centers. The files of children with MEFV gene carriers were retrospectively reviewed between February 2014 and May 2024.

Cognitive performance, psychiatric comorbidities, and quality of life in pediatric patients with juvenile idiopathic arthritis: a comparative analysis with healthy controls.

This study aimed to assess the extent of cognitive impairment in children and adolescents with Juvenile Idiopathic Arthritis (JIA). While cognitive deficits are recognized in other systemic rheumatic diseases, exploration within the pediatric JIA population remains limited. The investigation utilized a comprehensive approach to examine neuropsychological test performance.

EEG biomarkers in Alzheimer's and prodromal Alzheimer's: a comprehensive analysis of spectral and connectivity features.

Background: Biomarkers of Alzheimer's disease (AD) and mild cognitive impairment (MCI, or prodromal AD) are highly significant for early diagnosis, clinical trials and treatment outcome evaluations. Electroencephalography (EEG), being noninvasive and easily accessible, has recently been the center of focus. However, a comprehensive understanding of EEG in dementia is still needed.

Evaluation of bladder capacity in pediatric patients with nocturnal enuresis using voiding diary and uroflowmetry: A retrospective study.

Objective: This retrospective study was conducted in a tertiary hospital in Turkiye, it was aimed to evaluate the results of kidney and bladder ultrasonography, uroflowmetric study and volume frequency chart in children diagnosed with bedwetting at night.

Methods: This study focused on patients aged 5-17 years who were treated for nocturnal enuresis in the single-center pediatric urology clinic of a tertiary hospital between 2017-2021. Patients' comorbidities, surgical history, urinary ultrasonography findings, uroflowmetry examination results, and two-day voiding diary were requested.

Understanding Career Adapt Abilities, Career Stress, Work Stress, Career Regret, Job Satisfaction Among Nursing Professionals.

Aim: This study aims to conduct a comprehensive analysis of the interrelationships among career stress, work stress, career regret, job satisfaction and career adapt abilities within the nursing profession.

Design: The research involved a sample of 576 nurses from ten urban hospitals, distributed across five distinct cities in Turkiye, between December 2023 and January 2024. The study employed regression models to systematically test hypotheses, providing nuanced insights into the complex dynamics of the variables under investigation.