Publications by authors named "Arif Sadi"
Effective intracellular communication between cellular organelles occurs at dedicated membrane contact sites (MCSs). Tether proteins are responsible for the establishment of MCSs, enabling direct communication between organelles to ensure organelle function and host cell homeostasis. While recent research has identified tether proteins in several bacterial pathogens, their functions have predominantly been associated with mediating inter-organelle communication between the bacteria containing vacuole (BCV) and the host endoplasmic reticulum (ER).
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- Intracellular bacterial pathogens manipulate host cell processes to create a suitable environment for their survival, with the Q fever bacterium using its Type 4 secretion system to form a specialized vacuole known as a CCV.
- The study identifies that the bacterial effector protein Vice interacts with specific lipids (like phosphatidylserine) and triggers the formation of compartments similar to CCVs in host cells, demonstrating its role in both vacuole formation and stabilization.
- Vice performs dual functions: first aiding in the internalization of vacuoles through macropinocytosis, and then disrupting the ESCRT machinery to maintain these compartments, highlighting its key role in bacterial replication and survival.
Effective intracellular communication between cellular organelles is pivotal for maintaining cellular homeostasis. Tether proteins, which are responsible for establishing membrane contact sites between cell organelles, enable direct communication between organelles and ultimately influence organelle function and host cell homeostasis. While recent research has identified tether proteins in several bacterial pathogens, their functions have predominantly been associated with mediating inter-organelle communication specifically between the bacteria containing vacuole (BCV) and the host endoplasmic reticulum (ER).
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