Bacillus Calmette-Guerin (BCG) infections following intravesical BCG immunotherapy: a systematic review protocol.

Background: Although intravesical Bacillus Calmette-Guerin (BCG) immunotherapy usually exhibits a favorable safety profile, it can lead to the development of BCG infections, both localized and disseminated. Understanding of BCG infections following intravesical BCG immunotherapy is limited because of the lack of consensus definitions of BCG infections and limited post-instillation follow-up. We aim to perform a systematic review of the literature of BCG infections following intravesical BCG immunotherapy to elucidate the epidemiology, risk factors, and outcomes of BCG infections.

Design, Development, and Testing of Machine Learning Models to Estimate Properties of Friction Stir Welded Joints.

This paper estimates friction stir welded joints' ultimate tensile strength (UTS) and hardness using six supervised machine learning models (viz., linear regression, support vector regression, decision tree regression, random forest regression, K-nearest neighbour, and artificial neural network). Tool traverse speed, tool rotational speed, pin diameter, shoulder diameter, tool offset, and tool tilt are the six input parameters in the 200 datasets for training and testing the models.

Histologic, histochemical, and immunohistochemical changes in buffalo liver with cystic echinococcosis.

The present study aimed to evaluate the histologic, histochemical, and immunohistochemical changes in buffalo livers with cystic echinococcosis. Noninfected and infected livers were collected from the freshly slaughtered buffalo at the Aligarh abattoir. Small pieces of both infected and noninfected livers ( = 5) were cut and processed for histologic and histochemical studies.

The Molecular Detection and Therapeutic Management of Pathogenic Infection in a Goat: A Case Report.

A 2-year-old female Assam Hill goat was presented with a clinical history of anorexia, fever, mild anemia, rough body coat, dehydration, tachycardia, dyspnea and swelling of palpable lymph nodes. Hematology revealed low hemoglobin, packed cell volume, red blood cell and thrombocyte count. Biochemical analysis showed increased serum concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and urea in comparison to the normal reference range.

Infrastructure and resourcing of diversity, equity, inclusion, and accessibility initiatives across US pharmacy schools.

Objectives: This study assesses the infrastructure and resources surrounding diversity, equity, inclusion, and accessibility (DEIA) efforts in pharmacy education. The objectives were to investigate leadership roles and qualifications, resource commitment, challenges faced, and proudest accomplishments related to DEIA initiatives in colleges and schools of pharmacy.

Methods: A 27-question survey was distributed to CEO deans of US colleges and schools of pharmacy.

Allogeneic Stem Cell Transplant in Hematological Disorders: A Decade of Experience.

: Allogeneic hematopoietic cell transplantation (allo-HCT) is a complex procedure with the potential to provide curative treatment for various hematological disorders. This study aims to evaluate the outcomes of allo-HCT in hematological diseases and identify significant complications in a single-center setting. : We conducted a retrospective analysis of 180 patients with hematological diseases who underwent allo-HCT between January 2011 and December 2021.

Suboptimal Vaccination Coverage and Serological Screening in Western Australian Children With Inflammatory Bowel Disease Receiving Immunosuppressive Therapy: An Opportunity for Improvement.

Background Patients with inflammatory bowel disease (IBD) face an increased likelihood of severe illnesses, including those caused by vaccine-preventable diseases. Consequently, the purpose of this study was to evaluate both vaccination rates and serological screening in children with IBD in Western Australia, focusing on compliance with routine and additional vaccines, and pre-treatment screening for infections before starting immunosuppressive (IS) treatment. Method The study was conducted at Perth Children's Hospital (PCH) from June 2021 to February 2022, focusing on children aged 0-18 with confirmed IBD diagnoses.

The Role of Omega-3 Fatty Acid Supplementation in Slowing Cognitive Decline Among Elderly Patients With Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials.

This systematic review explores the impact of omega-3 fatty acid supplementation, particularly docosahexaenoic acid (DHA), on cognitive decline in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Omega-3 fatty acids are widely recognized for their neuroprotective properties, but the evidence regarding their efficacy in mitigating cognitive decline remains mixed. Through a comprehensive analysis of eleven randomized controlled trials, we aimed to assess the role of DHA in improving cognitive functions and slowing brain atrophy.

Nanostructured lipid carriers as a strategy to enhance oral levosulpiride delivery: An in vitro and ex vivo assessment.

Oral absorption is limited for many small-molecule drugs due to their poor aqueous solubility as well as, for some, poor membrane permeation. One such is levosulpiride (LSP), used to treat psychotic and other conditions. The present study aims to explore the effect of nanostructured lipid carriers (NLCs) for the delivery of LSP.

Potassium channels mediate nitric oxide-induced vasorelaxation in arteries supplying colon cancer.

Introduction: Aberrant vascular function and cancer growth are closely related, with nitric oxide (NO) being a key factor in vascular tone regulation. This study provides Novel insights into the distinctive mechanisms underlying cancer-associated vascular dysfunction by investigating the involvement of potassium (K) channels in NO-mediated vasorelaxation within arteries supplying colon cancer.

Methods: Arterial segments from colon cancer patients were isolated and sectioned into rings, these rings were mounted in an organ bath filled with Krebs' solution and maintained at 37°C.

Identification of RxLR Effector Genes Genome Sequencing.

is a significant phytopathogen causing downy mildew disease in cucurbit crops. Understanding the molecular mechanisms underlying the interaction between and its host is essential for developing effective disease management strategies. RxLR effectors, secreted by pathogens, play a crucial role in modulating host immunity.

Green synthesized silicon dioxide nanoparticles (SiONPs) ameliorated the cadmium toxicity in melon by regulating antioxidant enzymes activity and stress-related genes expression.

Green synthesized nanoparticles (NPs) are an eco-friendly and cost-effective approach to reduce heavy metal stress in plants. Among heavy metals, cadmium (Cd) possesses higher toxicity to the crops and ultimately reduces their growth and yield. The current study aims to evaluate the effectiveness of green synthesized SiONPs to reduce toxic effects of Cd in melon (Cucumis melo) by regulating physiological parameters, enhancing antioxidant enzyme activity, and modulating stress-related gene expression.

How to Manage a Large Undifferentiated Lung Cancer Mass: A Case Report.

Non-small cell lung cancer is the most common type of lung cancer globally. An important subtype to discuss is undifferentiated carcinomas, which are variants of large cell carcinoma, and these can typically present with evidence of neuroendocrine differentiation. The patient presented with a large mass in the right upper lobe extending into the middle lobe.

Distribution of HPV Types in Cervical Cancer in Pakistan: Implications for Screening and Vaccination Programs.

Background: HPV plays a key role in the development of cervical cancer. This study aims to investigate the prevalence of HPV genotypes in patients with Squamous cell carcinoma (SSC) and Adenocarcinoma (ADC) at NORI cancer Hospital Pakistan, with the aim of improving screening and prevention strategies.

Method: Cervical scrapings were collected from 129 diagnosed cervical cancer patients.

Frequency, clinical presentation and management of primary amenorrhea in a tertiary care setting.

Objective: We aimed to determine frequency, clinical presentation, etiology and management in patients presenting with primary amenorrhea in tertiary care setting.

Method: This was a case series conducted in outpatient Department of Gynecology and Obstetrics unit II, Dr. Ruth K.

Extracellular vesicle-packed microRNAs profiling in Alzheimer's disease: The molecular intermediary between pathology and diagnosis.

MicroRNAs (miRNAs), referring to a type of non-coding RNAs functioning in various biological processes, participate in the pathophysiology of Alzheimer's disease (AD) through increasing amyloid-beta (Aβ) production, enhancing Tau phosphorylation, and inducing neuroinflammation. Meanwhile, extracellular vesicles (EVs) have been suggested as promising carriers of AD biomarkers as they possess the ability to transmit information from cerebral tissue to peripheral blood. Inspired by the above findings, we in this review systematically generalized the roles of miRNAs in AD and explored the potential of EV-packed miRNA as biomarkers for early diagnosis of AD.

RELATIONSHIP OF MATERNAL MORBIDITY AND MORTALITY TO HIGH BODY MASS INDEX (BMI) PREGNANCIES IN PAKISTAN.

Background: The average BMI is shifting upwards even in low-resource countries like Pakistan causing an increase in pregnancy-related complications. This study was planned to elaborate the association of maternal morbidity and mortality during pregnancy and puerperium with high BMI.

Methods: A descriptive longitudinal study was performed in the Obstetrics and Gynaecology Unit 2 of D.

Risk Factors for Invasive Surgical Site Infections Among Adult Single Liver Transplant Recipients at Duke University Hospital in the Period 2015-2020.

Background: Invasive primary surgical site infections (IP-SSI) are a severe complication of liver transplant surgery. Identification of risk factors for IP-SSI is critical to IP-SSI prevention.

Methods: All adult single liver transplants performed at Duke University Hospital in the period 2015-2020 were reviewed for IP-SSI occurring within 90 d of transplant.

Functional and imaging outcomes of the Fontan circulation following pregnancy.

Introduction: The Fontan circulation palliates single-ventricle congenital heart disease by separating the systemic and pulmonary circulations. An increasing number of women with a Fontan circulation are wishing to become pregnant, however the ability to increase cardiac output during pregnancy is limited in many due to the chronic low output state. We describe pregnancy outcomes in these women at a large tertiary centre, including functional and imaging outcomes.

Smartphone-integrated inkjet-printed paper sensor and UV/Vis spectrophotometric method for on-site detection of As and L-cysteine in food samples using novel AMTPP-functionalized silver nanoparticles.

The increasing prevalence of arsenic (As) in water and its health impacts necessitate advanced detection methods. Similarly, monitoring L-Cysteine, a vital thiol-containing amino acid, is crucial for assessing physiological processes and disorders. This study presents a novel method for detecting As and L-Cysteine in food samples using 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole (AMTPP) functionalized silver nanoparticles (AMTPP-AgNPs) by UV/Vis spectrophotometric method and smartphone-assisted inkjet-printed paper-based sensors.

Pattern and associated factors of COVID-19 knowledge, attitude and practice (KAP) among COVID-19-comorbid patients: a systematic review and meta-analysis.

Background: The COVID-19 comorbid population is at higher risk of developing severe health issues like acute respiratory distress syndrome, coagulation syndrome, metabolic acidosis, and septic shock, potentially leading to patient death. Patients' knowledge, attitudes, and practices (KAP) significantly influence their response to the pandemic and aid in enhancing health policy implementation.

Objective: To identify and evaluate the pattern and associated factors to COVID-19 knowledge, attitude, and practice among individuals with comorbidities.

Signaling pathways in HPV-induced cervical cancer: Exploring the therapeutic promise of RNA modulation.

Cervical cancer, originating from the epithelial tissue of the uterine cervix, constitutes the most commonly diagnosed malignancy among women worldwide. The predominant etiological factor underpinning cervical carcinogenesis is persistent infection with high-risk human papillomavirus (HPV) genotypes, notably HPV-16 and HPV-18. Oncoproteins encoded by high-risk HPV interfere with multiple essential cellular signaling cascades.