Protein-C deficiency presenting as pulmonary embolism and myocardial infarction in the same patient.

Plasma protein-C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism.

Transcatheter aortic valve implantation with Core Valve: first Indian experience of three high surgical risk patients with severe aortic stenosis.

The prevalence of aortic stenosis is increasing with aging population. However with multiple co-morbidities and prior procedures in this aging population, more and more patients are being declared unfit for the 'Gold Standard' treatment i.e.

Low-dose dobutamine echocardiography predicts recovery of left ventricular systolic function following revascularization even in presence of low contractile reserve.

Background: Coronary revascularization is known to improve left ventricular ejection function (LVEF) in patients with severe left ventricular systolic dysfunction if there is myocardial viability and contractile reserve is >40% as determined by low-dose dobutamine echocardiography (LDDE). We tried to assess effect of coronary revascularization on left ventricular systolic function in patients with low contractile reserve (40%).

Methods And Results: In a retrospective analysis we studied 114 consecutive patients with left ventricular systolic dysfunction (LVEF <40%) with low contractile reserve (<40%) as detected by LDDE (16-segment model).