Assessment of the clinical efficacy of a hyaluronic acid-based deep wrinkle filler using new instrumental methods.

Background: The efficacy of numerous hyaluronic acid (HA)-based fillers has been demonstrated by semi-quantitative and qualitative methods, useful in clinical practice, but poorly reliable.

Objective: To objectively evaluate the efficacy of a HA gel in treating nasolabial folds (NLFs) over a 9-12-month follow-up period.

Methods: A total of 47 adult patients with moderate to severe NLFs received one or two injections of HA gel.