Publications by authors named "Ariel Y Weinsaft"
Aims: Transthyretin cardiomyopathy (ATTR-CM) is characterized by episodes of worsening heart failure (WHF) which can include heart failure (HF) hospitalizations or urgent unplanned visits for administration of intravenous diuretics. WHF characterized by outpatient intensification of oral loop diuretics is common yet its prognostic implications for ATTR-CM patients relative to other WHF events remains unclear. We assessed how WHF characterized by outpatient diuretic intensification (ODI) relates to mortality in this population.
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- * The study found that anemia linked to higher risks for all-cause and cardiovascular hospitalizations, with significant statistics demonstrating this correlation.
- * Despite the correlation, when adjusting for age and other factors, anemia was mainly associated with an increased hazard for hospitalizations rather than mortality, highlighting the need for more research on how treating anemia might improve patient outcomes.
Article Synopsis
- The study examines the clinical outcomes of 419 patients diagnosed with transthyretin cardiac amyloidosis (ATTR-CA) from 2001 to 2021, focusing on changes in diagnosis and treatment over time.
- It found that more recent patients are generally older, have less severe disease, and are more likely to be treated with tafamidis, which significantly improves survival rates compared to earlier diagnosed patients.
- Key results show that a higher Columbia score indicates a greater risk of mortality or need for heart transplantation, while tafamidis notably decreases this risk, highlighting the importance of early treatment.