Publications by authors named "Ariel Osvaldo Zwenger"
Background: Parathyroid hormone-related peptide (PTHrP) plays a key role in the development and progression of many tumors. We found that in colorectal cancer (CRC) HCT116 cells, the binding of PTHrP to its receptor PTHR type 1 (PTHR1) activates events associated with an aggressive phenotype. In HCT116 cell xenografts, PTHrP modulates the expression of molecular markers linked to tumor progression.
View Article and Find Full Text PDFBackground: Probiotics are used to manage a number of gastrointestinal disorders due to their beneficial properties. Clinical reports showed that probiotics also improve the life quality of patients with colorectal cancer (CRC) subjected to oncologic treatment. In a CRC animal model, probiotics supplementation has the potential to decrease the formation of aberrant crypts and ameliorate tumor malignancy, enhancing the antitumor effect of 5-fluorouracil (5-FU) chemotherapy.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on women diagnosed with brain metastases at the same time as breast cancer, which is a rare and complex situation.
- In the analysis of 740 patients, the median overall survival was found to be 10 months, with only 20.7% surviving at 3 years; tumor subtype significantly influenced survival rates.
- Key findings indicated that triple-negative breast cancer had the shortest median survival of 6 months, while the HR+/HER2+ subtype had the longest, at 22 months; additional factors affecting survival included age, type of tumor histology, presence of liver metastases, and marital status.
Article Synopsis
- Male breast cancer (MaBC) is not well understood, especially regarding the treatment and outcomes for early-stage patients; this study analyzed characteristics, treatments, and survival rates of men with early-stage MaBC.
- The study included 1263 men diagnosed between 1988 and 2012, showing a 5-year overall survival (OS) rate of 85.1%, with older age, higher tumor grades, lack of surgery, and no lymph node examination correlating with poorer outcomes.
- Findings suggest that while men with early MaBC have generally good survival rates, there is a need to reconsider the high rates of mastectomy and extensive lymph node examination since breast conservation and fewer lymph nodes examined yield similar survival rates.
Prognostic factors in male breast cancer: a population-based study.
Breast Cancer Res Treat
April 2016
Article Synopsis
- The study investigated prognostic factors in male breast cancer (MaBC) by analyzing data from 2992 patients diagnosed between 2003 and 2012.
- Results showed that most MaBC cases were ductal, hormone receptor-positive, and early-stage, while grade I tumors were rare.
- Key findings indicated that older age, higher tumor grades, advanced disease stage, lack of surgery or radiotherapy, ER negativity, and being unmarried were linked to shorter overall survival.
Article Synopsis
- - The study aims to assess the characteristics and prognostic implications of different tumor subtypes in male breast cancer (MaBC), specifically analyzing data from 960 patients recorded between 2010 and 2012.
- - Patients were categorized into four subtypes based on hormone receptor (HR) and HER2 status, revealing that triple-negative (TN) patients tended to be younger and had poorer outcomes compared to other subtypes.
- - Univariate and multivariate analyses showed that factors like HER2 positivity, tumor stage, and being older significantly impacted overall survival (OS), emphasizing that tumor subtype plays a vital role in prognosis alongside age and stage.
Sixteen years follow-up results of a randomized phase II trial of neoadjuvant fluorouracil, doxorubicin, and cyclophosphamide (FAC) compared with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in stage III breast cancer: GOCS experience.
Breast Cancer Res Treat
January 2014
Article Synopsis
- * After analyzing data from 126 patients over a median follow-up of 4.5 years, the two chemotherapy regimens exhibited similar objective response rates and survival outcomes, with no significant differences in disease-free or overall survival.
- * The study found that the number of pathologically involved lymph nodes was the strongest predictor of survival, and while both regimens were tolerated, CMF had more severe blood-related side effects, while FAC was linked to more hair loss.