The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.

Adolescents With Eating Disorders in Pediatric Practice - The European Academy of Paediatrics Recommendations.

In the face of the growing number of adolescents suffering from eating disorders (EDs) and access to psychiatric care limited by the epidemiological and demographic situation, the primary care pediatrician's role in diagnosing and treating EDs is growing. The European Academy of Paediatrics (EAP) decided to summarize knowledge about EDs and formulate recommendations to support European pediatricians and improve care for adolescents with EDs.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.

Expert appraisal of criteria for assessing gaming disorder: an international Delphi study.

Background And Aims: Following the recognition of 'internet gaming disorder' (IGD) as a condition requiring further study by the DSM-5, 'gaming disorder' (GD) was officially included as a diagnostic entity by the World Health Organization (WHO) in the 11th revision of the International Classification of Diseases (ICD-11). However, the proposed diagnostic criteria for gaming disorder remain the subject of debate, and there has been no systematic attempt to integrate the views of different groups of experts. To achieve a more systematic agreement on this new disorder, this study employed the Delphi expert consensus method to obtain expert agreement on the diagnostic validity, clinical utility and prognostic value of the DSM-5 criteria and ICD-11 clinical guidelines for GD.

Catalogue of New Zealand land, freshwater and estuarine molluscan taxa named by Frederick Wollaston Hutton between 1879 and 1904.

Details are provided on 16 land snail genera, eight freshwater molluscan species, one estuarine species, 47 land snail species and varieties from New Zealand, and a further three land snail species putatively from New Zealand, which were described by Frederick Wollaston Hutton between 1879 and 1904. Original primary type material of 54 species was located during the present study. Lectotypes are designated for: Amphidoxa cornea Hutton, 1882, Amphidoxa jacquenetta Hutton, 1883, Amphidoxa perdita Hutton, 1883, Charopa cassandra Hutton, 1883, Cyclotus charmian Hutton, 1883, Fruticicola adriana Hutton, 1883, Gerontia cordelia Hutton, 1883, Gerontia pantherina Hutton, 1882, Microphysa pumila Hutton, 1882, Patula jessica Hutton, 1883, Patula lucetta Hutton, 1884, Patula sylvia Hutton, 1883, Patula tapirina Hutton, 1882, Pfeifferia cressida Hutton, 1883, Phrixgnathus celia Hutton, 1883, Phrixgnathus haasti Hutton, 1883, Phrixgnathus marginatus Hutton, 1882, Phrixgnathus phrynia Hutton, 1883, Rhytida australis Hutton, 1882, Strobila leiodon Hutton, 1882, Thalassia propinqua Hutton, 1882, Therasia thaisa Hutton, 1883, Therasia valeria Hutton, 1883 and Zonites helmsii Hutton, 1882.

Including gaming disorder in the ICD-11: The need to do so from a clinical and public health perspective.

The proposed introduction of gaming disorder (GD) in the 11th revision of the International Classification of Diseases (ICD-11) developed by the World Health Organization (WHO) has led to a lively debate over the past year. Besides the broad support for the decision in the academic press, a recent publication by van Rooij et al. (2018) repeated the criticism raised against the inclusion of GD in ICD-11 by Aarseth et al.

Intensive meditation training influences emotional responses to suffering.

Meditation practices purportedly help people develop focused and sustained attention, cultivate feelings of compassionate concern for self and others, and strengthen motivation to help others who are in need. We examined the impact of 3 months of intensive meditative training on emotional responses to scenes of human suffering. Sixty participants were assigned randomly to either a 3-month intensive meditation retreat or a wait-list control group.

Enhanced response inhibition during intensive meditation training predicts improvements in self-reported adaptive socioemotional functioning.

We examined the impact of training-induced improvements in self-regulation, operationalized in terms of response inhibition, on longitudinal changes in self-reported adaptive socioemotional functioning. Data were collected from participants undergoing 3 months of intensive meditation training in an isolated retreat setting (Retreat 1) and a wait-list control group that later underwent identical training (Retreat 2). A 32-min response inhibition task (RIT) was designed to assess sustained self-regulatory control.

Toxicology information resources at the Environmental Protection Agency.

Article presents toxicology information resources available to the public from the United States Environmental Protection Agency (EPA). This includes digital information directly usable or downloadable from their web site, or referrals as to where the resource can be obtained. Contents include advice on effective search strategies, a 'guided tour' of the web site and its main categories, and concludes with an extensive annotated bibliography of toxicological databases.

Magnesium regulates hypoxia-stimulated apoptosis in the human placenta.

Apoptosis (programmed cell death) in the human placenta is likely to play a major role in determining the structure and function of that organ. Fetal growth restriction (FGR) has been shown to be associated with increased levels of placental apoptosis. Altered regulation of apoptosis may play an important pathophysiological role in FGR.

Autacoid interactions in the regulation of blood flow in the human placenta.

1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were determined.