Exploring non-covalent interactions in excited states: beyond aromatic excimer models.

Time-dependent density functional theory (TD-DFT) offers a relatively accurate and inexpensive approach for excited state calculations. However, conventional TD-DFT may suffer from the same poor description of non-covalent interactions (NCIs) which is known from ground-state DFT. In this work we present a comprehensive benchmark study of TD-DFT for excited-state NCIs.

Micafungin activity against Candida bloodstream isolates: effect of growth medium and susceptibility testing method.

An excellent correlation between micafungin MICs were demonstrated against Candida bloodstream isolates (n = 200) by the Sensititre YeastOne and National Committee for Clinical Laboratory Standards M27-A2 methods. Use of antibiotic medium 3 (2%) dextrose improved micafungin activity and was not associated with paradoxical growth as noted with 3 Candida isolates tested using RPMI (2%) dextrose.

Altered susceptibility of Candida glabrata bloodstream isolates to triazoles at clinically relevant pH values: comparison of the NCCLS M27-A2, Sensititre YeastOne, and Etest methods.

We studied the MICs of triazoles against 15 Candida glabrata clinical isolates by the NCCLS M27-A2, Sensititre YeastOne, and Etest methods by using media at pHs 6.0, 7.0, and 7.