Publications by authors named "Arianna Turati"
Neuroscience
November 2018
Article Synopsis
- Pathological Tau (P-Tau) is linked to dementia and neurodegeneration, with P301L transgenic mice serving as a model that reflects human tauopathy, showing sex differences in severity, particularly worse in females.
- JNK activation in these mice suggests its involvement in degenerative processes, with increased levels of key proteins indicating heightened synaptic dysfunction and behavioral defects, especially in female mice.
- As current treatments for synaptic pathology are lacking, targeting the JNK pathway with specific inhibitors could be a promising strategy for addressing P-Tau-related neurological issues.
