Publications by authors named "Arianna Lanzi"
Background: People who inject drugs (PWID) are the largest group at risk for HCV infection. Despite the direct acting antivirals (DAA) advancements, HCV elimination has been hindered by real-life difficulties in PWID.
Aims: This study aimed to assess the impact of a multidisciplinary intervention strategy where HCV screening, treatment and follow-up were performed at the same location on efficacy and safety of DAA-therapy in real-life PWID population.
Background: The estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.
Methods: The Bagnacavallo Study was performed between October 2005 and March 2009. All the citizens of Bagnacavallo (Ravenna, Italy) aged 30 to 60 years as of January 2005 were eligible.
Introduction: Although sorafenib is the upfront standard of care for advanced hepatocellular carcinoma (HCC), molecular predictors of efficacy have not been identified yet. In the ALICE-1 study, rs2010963 of VEGF-A and VEGF-C proved to be independent predictive factors for progression-free survival (PFS) and overall survival (OS) in multivariate analysis. The ALICE-1 study results were confirmed in the ALICE-2 study, in which VEGF and VEGFR SNPs were analyzed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates factors that affect liver stiffness measurement (LSM) in both healthy individuals and those with non-alcoholic fatty liver disease (NAFLD).
- Among 780 participants, LSM values were established, showing healthy individuals had a median LSM of 4.4kPa, which was not influenced by demographic factors except for insulin resistance.
- In NAFLD patients, LSM was significantly higher, with severe steatosis and diabetes being notable contributors to increased LSM values.
Amyotrophic Lateral Sclerosis (ALS) is a degeneration of somatic motor neurons extending from upper motor cortical pyramidal neurons to lower motor neurons of the brainstem and cord. During the course of the disease patients require invasive procedures for nutrition and ventilation. Percutaneous Endoscopic Gastrostomy (PEG), performed in patients with impaired swallowing, is a safe procedure for the administration of Enteral Nutrition (EN).
View Article and Find Full Text PDFThe urea cycle is the final pathway for nitrogen metabolism. Urea cycle disorders (UCDs) include a variety of genetic defects, which lead to inefficient urea synthesis. Elevated blood ammonium level is usually dominant in the clinical pattern and the primary manifestations affect the central nervous system.
View Article and Find Full Text PDFCryoglobulinemia in elderly patients with HCV-related chronic hepatitis.
World J Gastrointest Pharmacol Ther
April 2010
Hepatitis C virus (HCV) infection affects about 3% of the world's population and often leads to chronic liver disease. In some industrialized countries, HCV prevalence increases with age, but the optimal management of older patients has not been accurately defined. HCV infection can also lead to lymphoproliferative disorders, the most common being mixed cryoglobulinemia (MC), and also for this condition that frequently affects elderly patients, the optimal therapeutic strategy is still debated.
View Article and Find Full Text PDFWe describe a case of worsening paraparesis induced by spinal cord compression at T6-T7 levels associated with compensatory extramedullary haematopoiesis from a compound heterozygote for haemoglobin E and for β-thalassemia. An emergency T3-T9 laminectomy was performed with excision of the masses and complete rehabilitation of the patient.
View Article and Find Full Text PDFObjective: Ultrasonography is the first examination performed for screening of hepatocellular carcinoma (HCC); contrast-enhanced ultrasonography (CEUS) can help discriminate between HCC and other lesions. Primary hepatic lymphoma (PHL), even if rare, should be considered in the differential diagnosis of focal liver lesions (FLLs). Few data are available in the literature about the role of CEUS in the diagnosis of PHL; we tried to determine whether CEUS could have a role in this setting.
View Article and Find Full Text PDFLiver AL amyloidosis as a possible cause of high liver stiffness values.
Eur J Gastroenterol Hepatol
July 2010
Article Synopsis
- The liver is commonly affected by amyloid deposits in systemic amyloidosis, as seen in a case study of a 52-year-old woman with symptoms including liver enlargement and abnormal liver enzyme levels.
- Laboratory tests revealed proteinuria with lambda light chains, and imaging showed an enlarged liver with normal blood flow.
- Diagnosis was supported by a fat biopsy showing amyloid presence, alongside tests indicating high liver stiffness, confirming amyloid infiltration and low-grade plasmacytoma with amyloidosis without needing a liver biopsy.
Background: Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration.
Aims: This study aims to analyse the expression of Notch3, Notch4 and HES1 and HES6 as Notch-target genes in HCC, matched non-neoplastic tissue and HEPG2 cells.
Results: Notch3 and Notch4 are not expressed in normal liver and in chronic hepatitis surrounding HCC.