Publications by authors named "Arianna Landini"
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but only a few were functionally validated.
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- Post-translational modifications (PTMs) play a crucial role in protein function and cell signaling, yet their genetic regulation is still not fully understood.
- This study compares the genetic regulation of glycosylation in two proteins, transferrin and immunoglobulin G (IgG), identifying new genetic loci associated with transferrin glycosylation.
- The findings reveal that while some genes affecting glycosylation are specific to each protein, there are also shared genetic influences, indicating a complex interplay in how these modifications are regulated.
Article Synopsis
- - Changes in the N-glycosylation of immunoglobulin G (IgG) are linked to various diseases, but it's unclear if these changes are a cause or a result of the diseases.
- - This study used a method called two sample Mendelian randomization (MR) to analyze the relationship between IgG N-glycosylation traits and 12 diseases, finding a positive causal effect of systemic lupus erythematosus (SLE) on specific IgG glycosylation patterns.
- - The authors recommend considering the glycosylation trait as a potential biomarker for SLE and highlight the need for more comprehensive genome-wide association studies (GWAS) to better understand the connections between Ig
Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19.
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- The adoption of rice as a staple in many Asian diets has significantly impacted nutritional habits and created challenges in managing blood sugar levels due to rice's high carbohydrate content and glycemic index.
- Epidemiological data shows differences in type 2 diabetes and obesity rates among Asian populations, with South Asians experiencing higher prevalence than East Asians, potentially due to historical dietary adaptations.
- Genetic analysis of various East and South Asian populations suggests that those with a long history of rice or millet consumption may have developed biological adaptations to mitigate the negative effects of high carbohydrate diets.