Publications by authors named "Arianna Catelli"
Activated phosphoinositide 3-kinase-δ syndrome 2 (APDS2) is characterized by lymphoproliferation and increased risk of malignancy. FDG-PET/CT may represent a helpful diagnostic tool for differentiating these clinical features and correctly diagnosing inborn errors of immunity (IEI). We present the case of a female patient diagnosed with Hodgkin's lymphoma at 19 years of age, although atypical imaging aspects emerged: baseline FDG-PET/CT revealed several hot lymph nodes with a symmetrical distribution, and increased tracer uptake in spleen, axial, and appendicular bone marrow.
View Article and Find Full Text PDFBackground: The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflammatory therapy, in the treatment of IEI-related immune dysregulation disorders, according to labelled and off-label indications. Recent years have been dominated by a progressive imbalance between the gradual but constant increase in the use of immunoglobulins and their availability, exacerbated by the SARS-CoV-2 pandemic.
Objectives: To provide pragmatic indications for a need-based application of high-dose immunoglobulins in the pediatric context.
Diet is a matter of interest in the pathogenesis and management of Crohn's Disease (CD). Little is known about CD children's dietary habits. Our aim was assessing the quality and the amount of nutrient intake in a group of CD pediatric patients.
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- - The text serves as a correction to an article with the DOI 10.3389/fped.2021.702546, indicating that there were errors or updates that need to be addressed.
- - The original publication likely contained inaccuracies or incomplete information that has now been rectified.
- - This correction is important for ensuring the integrity and accuracy of the research presented in the referenced article.
Article Synopsis
- - Activated phosphoinositide 3-kinase-δ syndrome 2 (APDS2) is a rare immune disorder caused by a mutation in the gene that regulates a specific enzyme, leading to hyperactivation and various clinical symptoms like recurrent infections, autoimmunity, and increased cancer risk.
- - The article presents a case of a 30-year-old woman with APDS2 who struggled with systemic lupus erythematosus, Hodgkin's lymphoma, and severe immune system dysfunction, including low immunoglobulin levels and persistent inflammation despite treatment.
- - This case highlights the need for healthcare professionals to consider primary immune regulatory disorders in young adults with severe immune issues, as early diagnosis can facilitate targeted treatments.
Asthma exacerbations are associated with significant childhood morbidity and mortality. Recurrent asthma attacks contribute to progressive loss of lung function and can sometimes be fatal or near-fatal, even in mild asthma. Exacerbation prevention becomes a primary target in the management of all asthmatic patients.
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