Publications by authors named "Arianna Castagna"
Article Synopsis
- - This study introduces a new high-dimensional technique to analyze human γδ T cell subsets in their natural tissue settings, overcoming previous challenges related to antibody availability and technology limitations.
- - Researchers utilized a combination of multiplexed imaging and bioinformatics to identify and characterize γδ T cells in colon and colorectal cancer samples, uncovering various microenvironments and their interactions with both immune and cancer cells.
- - Although this initial study shows the promise of this advanced technology for exploring T cell diversity and microenvironments, further research is needed to connect specific T cell characteristics and microenvironment features with important clinical factors.
Background: The poor prognosis of ovarian cancer patients is strongly related to peritoneal metastasis with the production of malignant ascites. However, it remains largely unclear how ascites in the peritoneal cavity influences tumor metabolism and recurrence. This study is an explorative approach aimed at for a deeper molecular and physical-chemical characterization of malignant ascites and to investigate their effect on in vitro ovarian cancer cell proliferation.
View Article and Find Full Text PDFBackground: We tested the feasibility of ultrasound technology for generating pressurized intraperitoneal aerosol chemotherapy (usPIPAC) and compared its performance vs. comparator (PIPAC).
Material And Methods: A piezoelectric ultrasound aerosolizer (NextGen, Sinaptec) was compared with the available technology (Capnopen, Capnomed).
Objectives: Biopsy morphology (surface/depth ratio) and sample processing might affect pharmacological measurements in peritoneal tissue.
Methods: This is an study on inverted bovine urinary bladders (IBUB). We compared cisplatin (CIS) and doxorubicin (DOX) concentration in 81 standardized transmural punch biopsies of different diameters (6 and 12 mm).
To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders . The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC).
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