GPR41 and GPR43 regulate CD8 T cell priming during herpes simplex virus type 1 infection.

Naïve CD8 T cells need to undergo a complex and coordinated differentiation program to gain the capacity to control virus infections. This not only involves the acquisition of effector functions, but also regulates the development of a subset of effector CD8 T cells into long-lived and protective memory cells. Microbiota-derived metabolites have recently gained interest for their influence on T cells, but much remains unclear about their role in CD8 T cell differentiation.