Physico-chemical solid-state characterization of omeprazole sodium: thermal, spectroscopic and crystallinity studies.

The physical characterization of active pharmaceutical substances is crucial to the successful development of the final drug product. The different solid forms and variations in the degree of crystallinity can lead to significantly different physical and chemical properties, including color, morphology, stability, dissolution and bioavailability. In the case of omeprazole sodium (OMS), its chemical structures contain a specific number of water molecules (hydrate).

Delta(9)-THC administered into the medial prefrontal cortex disrupts the spatial working memory.

Rationale: Delta(9)-Tetrahydrocannabinol (Delta(9)-THC) disrupts working memory. The prefrontal cortex (PFC) is involved in the processing of working memory, and its medial portion (mPFC) is part of a brain reward circuit as constituted by the mesocorticolimbic dopaminergic system.

Objective: This study examined the involvement of the mPFC in the effects of Delta(9)-THC on spatial working memory.