Publications by authors named "Ariane Julio Rivellis"
Determination of serum levels of imatinib mesylate in patients with chronic myeloid leukemia: validation and application of a new analytical method to monitor treatment compliance.
Vinícius Marcondes Rezende Ariane Julio Rivellis Melissa Medrano Gomes Felipe Augusto Dörr Mafalda Megumi Yoshinaga Novaes
Rev Bras Hematol Hemoter
June 2013
Objective: The goal of this study was to monitor imatinib mesylate therapeutically in the Tumor Biology Laboratory, Department of Hematology and Hemotherapy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP). A simple and sensitive method to quantify imatinib and its metabolite (CGP74588) in human serum was developed and fully validated in order to monitor treatment compliance.
Methods: The method used to quantify these compounds in serum included protein precipitation extraction followed by instrumental analysis using high performance liquid chromatography coupled with mass spectrometry.