Publications by authors named "Ariane Fontes Dias"
Sex-specific effect of antenatal Zika virus infection on murine fetal growth, placental nutrient transporters, and nutrient sensor signaling pathways.
Daniela Pereira-Carvalho Alessandra Cristina Chagas Valim Cherley Borba Vieira Andrade Enrrico Bloise Ariane Fontes Dias Wagner Barbosa Dias
FASEB J
July 2024
Article Synopsis
- - Maternal Zika virus (ZIKV) infection during pregnancy leads to serious complications like intrauterine growth restriction and neurological issues in newborns, and this study focuses on how ZIKV affects nutrient transport in the placenta.
- - In experiments with mice, male fetuses showed impaired growth and different responses in placental markers compared to female fetuses; male placentae exhibited lower nutrient transporter activity while female placentae had altered glucose transport mechanisms.
- - The research highlights sex-dependent differences in how the placenta responds to ZIKV, suggesting that understanding these mechanisms could help develop treatments for the complications associated with congenital Zika syndrome.
Thyroid hormones (THs) are required for the growth and development of the fetus, stimulating anabolism, and oxygen consumption from the early stages of pregnancy to the period of fetal differentiation close to delivery. Maternal changes in the hypothalamic-pituitary-thyroid axis are also well known. In contrast, several open questions remain regarding the relationships between the placenta and the maternal and fetal TH systems.
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