Publications by authors named "Ariana S Safi"
Background: Despite the success of first-generation COVID-19 vaccines targeting the spike (S) protein, emerging SARS-CoV-2 variants have led to immune escape, reducing the efficacy of these vaccines. Additionally, some individuals are unable to mount an effective immune response to S protein-based vaccines. This has created a need for alternative vaccine strategies that are less susceptible to mutations and capable of providing broad and durable protection.
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- * The vaccine was tested on various animals, including mice, rabbits, and marmoset monkeys, and showed safety and strong immune responses, including N-specific IgG and T cell responses.
- * In infected Syrian hamsters, the vaccine reduced lung damage and virus levels, demonstrating its effectiveness and potential to complement current COVID-19 vaccines.