Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.

Tau tubulin kinase 1 and 2 (TTBK1/2) are highly homologous kinases that are expressed and mediate disease-relevant pathways predominantly in the brain. Distinct roles for TTBK1 and TTBK2 have been delineated. While efforts have been devoted to characterizing the impact of TTBK1 inhibition in diseases like Alzheimer's disease and amyotrophic lateral sclerosis, TTBK2 inhibition has been less explored.

Spectroelectrochemical-Conductance Measurements as an Efficient Tool for the Evaluation of Charge Trapping in Conducting Polymers.

UV-vis-NIR spectroelectrochemistry has been intensively used to evaluate the electronic transitions during the charging/discharging process of π-conjugated polymers. However, the type of charge carrier and the mechanisms of their transport, remains still a point of discussion. Herein, the coupling between UV-vis-NIR spectroscopy and electrochemical-conductance measurements is proposed to compare the doping process of three different thiophene-based conducting polymers.

Generation of an induced pluripotent stem cell line (UNCCi002-A) from a healthy donor using a non-integration system to study Cerebral Cavernous Malformation (CCM).

The generation of induced pluripotent stem cells (iPSCs) from healthy individuals is an invaluable resource as reference control in disease modeling and drug discovery. This paper details the reprogramming of peripheral blood mononuclear cells (PBMCs) isolated from a healthy 27 years-old male using non-integration technology. The derived iPSCs displayed typical pluripotent stem cell morphology, the capacity to differentiate into the three germ layers, and normal karyotype.

Systemic Lupus Erythematosus and Its Association with Hemophagocytic Syndrome as an Initial Manifestation.

Hemophagocytic syndrome (HS) is a potentially fatal hyperinflammatory condition characterized by excessive activation of macrophages and T cells. Systemic lupus erythematosus (SLE) is an autoimmune condition that predisposes to HS. The appearance of SLE and HS is rare.

Organic Electrochemical Transistors (OECTs) Toward Flexible and Wearable Bioelectronics.

Organic electronics have emerged as a fascinating area of research and technology in the past two decades and are anticipated to replace classic inorganic semiconductors in many applications. Research on organic light-emitting diodes, organic photovoltaics, and organic thin-film transistors is already in an advanced stage, and the derived devices are commercially available. A more recent case is the organic electrochemical transistors (OECTs), whose core component is a conductive polymer in contact with ions and solvent molecules of an electrolyte, thus allowing it to simultaneously regulate electron and ion transport.

Synthesis of Carboxyl-EDOT as a Versatile Addition and Additive to PEDOT:PSS.

Two-step synthesis of EDOT (3,4-ethylenedioxythiophene) derivate bearing a carboxylic acid group (carboxyl-EDOT) is presented. This reactive monomer has been copolymerized with EDOT to afford PEDOT copolymers. Thanks to the most common additives usually added to the PEDOT:PSS dispersion, ethylene glycol and 4-dodecylbenzenesulfonic acid (DBSA), the carboxylic acid has been used to cross-link the material via esterification reactions.