Publications by authors named "Ariana Magedson"
Article Synopsis
- A study conducted at a public university in Seattle evaluated the effectiveness of SARS-CoV-2 antigen-detection rapid diagnostic tests (Ag-RDTs) in comparison to traditional rRT-PCR testing over a period from February to December 2022.
- Out of 5,757 participants, those who took 12,674 rRT-PCR tests found 7.9% positive, with Ag-RDTs showing an overall sensitivity of 53% and specificity of 98.8%.
- The study concluded that Ag-RDT sensitivity improved with sequential testing, particularly after initial negative results, and recommended repeat testing for symptomatic individuals or those at high risk.
SARS-CoV-2 Screening Testing in Schools: A Comparison of School- Vs. Home-Based Collection Methods.
J Pediatric Infect Dis Soc
December 2022
We implemented a voluntary SARS-CoV-2 screening testing study for kindergarten-2nd grade students in a Washington School district. Weekly SARS-CoV-2 testing participation was higher for students with staff-collected nasal swabs at school than for students with parent-collected swabs at home.
View Article and Find Full Text PDFArticle Synopsis
- Novel variants, especially Omicron, have emerged during the SARS-CoV-2 pandemic, prompting the need for effective genomic surveillance through university testing programs.* -
- From September 2021 to February 2022, a study at a university identified 1,730 Omicron genomes out of nearly 3,000 positive cases, revealing Omicron's quicker transmission compared to Delta.* -
- Even with high vaccination rates and strict health guidelines, Omicron outpaced Delta to become the dominant strain, resulting in a significant increase in COVID-19 cases within the university community.*
SARS-CoV-2 Epidemiology on a Public University Campus in Washington State.
Open Forum Infect Dis
November 2021
Background: We aimed to evaluate a testing program to facilitate control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission at a large university and measure spread in the university community using viral genome sequencing.
Methods: Our prospective longitudinal study used remote contactless enrollment, daily mobile symptom and exposure tracking, and self-swab sample collection. Individuals were tested if the participant was exposed to a known SARS-CoV-2-infected person, developed new symptoms, or reported high-risk behavior (such as attending an indoor gathering without masking or social distancing), if a member of a group experiencing an outbreak, or at enrollment.
A major goal of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine efforts is to elicit antibody responses that confer protection. Mapping the epitope targets of the SARS-CoV-2 antibody response is critical for vaccine design, diagnostics, and development of therapeutics. Here, we develop a pan-coronavirus phage display library to map antibody binding sites at high resolution within the complete viral proteomes of all known human-infecting coronaviruses in patients with mild or moderate/severe coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFThis cohort study analyzed persistent symptoms among adults with coronavirus disease 2019 up to 9 months after illness onset.
View Article and Find Full Text PDFBackground: Skilled nursing facilities (SNFs) are high-risk settings for SARS-CoV-2 transmission. Infection rates among employees are infrequently described.
Objective: To describe SARS-CoV-2 rates among SNF employees and residents during a non-outbreak time period, we measured cross-sectional SARS-CoV-2 prevalence across multiple sites in the Seattle area.