Publications by authors named "Ariana G Tyo"
Hydroxyl radical (OH) is a potent reactive oxygen species with the ability to degrade hazardous organic compounds, kill bacteria, and inactivate viruses. However, an off-the-shelf, portable, and easily activated biomaterial for generating OH does not exist. Here, microgels were functionalized with catechol, an adhesive moiety found in mussel adhesive proteins, and hematin (HEM), a hydroxylated Fe ion-containing porphyrin derivative.
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- Fibrin microparticles were mixed into PEG-fibrinogen hydrogels to develop an injectable composite that aids in wound healing and delivers therapeutic agents for tissue engineering.
- Nitric oxide (NO) was incorporated into the microparticles using a chemical solution, improving the swelling and tissue adhesion properties of the hydrogels.
- These composites enable controlled release of NO through light and heat activation, are non-toxic to cells, and help maintain cell health, making them promising for regenerative medicine in wound healing.