Publications by authors named "Ariana G Ojalvo"
Int Wound J
February 2017
Article Synopsis
- * This study explored the effects of epidermal growth factor treatment on patients with DFUs, focusing on markers of oxidative stress and antioxidant levels.
- * Results showed that DFU patients had high oxidative stress and low antioxidants, but treatment with epidermal growth factor improved their biochemical profiles, suggesting it helps restore redox balance.
Article Synopsis
- Wound chronification and opportunistic infections significantly contribute to lower limb amputations in diabetic patients, and the exact molecular reasons for slow healing are not fully understood.
- A case study of a female diabetic shows that after treating a plantar abscess, her wound still progressed poorly due to a lack of essential healing factors, revealing issues like poor matrix formation and limited blood vessel growth.
- The study suggests that diabetic fibroblasts exhibit premature aging due to increased levels of proteins that inhibit cell proliferation (like p53 and p21) and decreased levels of growth-promoting signals (like Akt and mTOR), leading to slow wound healing.
