Publications by authors named "Ariana Fantasia-Davis"
Aminoacyl-tRNA synthetases (aaRSs) are universally essential enzymes that synthesize aminoacyl-tRNA substrates for protein synthesis. Although most organisms require a single aaRS gene for each proteinogenic amino acid to translate their genetic information, numerous species encode multiple gene copies of an aaRS. Growing evidence indicates that organisms acquire extra aaRS genes to sustain or adapt to their unique lifestyle.
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- Human rotavirus (HRV) is a major cause of severe gastroenteritis in children, primarily affecting the gastrointestinal tract and causing symptoms like diarrhea and vomiting.
- Recent studies suggest that HRV might also infect salivary glands, similar to murine strains that transmit the virus through saliva between mother and pups.
- In a study using gnotobiotic pigs, researchers found that HRV was present in saliva, feces, and various tissues, indicating the virus can replicate in salivary tissues and trigger immune responses in both intestinal and facial lymphoid areas.
Article Synopsis
- Human rotavirus (HRV) is a leading cause of severe diarrhea in young children, particularly in low-income countries, where vaccine effectiveness is hampered by malnutrition and co-infections.
- A new two-dose intramuscular (IM) nanoparticle-based HRV vaccine was tested, showing good antibody responses but not significant protection against diarrhea; however, it did reduce the duration of virus shedding in pigs.
- Combining an oral vaccine with the IM nanoparticle vaccine improved immune responses, indicating the potential of this prime-boost strategy for better HRV prevention.