Publications by authors named "Ariadna Rivas-Souchet"
Article Synopsis
- C-N bond formation is vital for creating nitrogen-containing compounds in pharmaceuticals and agricultural chemicals, with alkene hydroamination being a key method, but it has challenges in achieving stereoselectivity for complex structures.
- The researchers developed a novel photoenzymatic process using a mutated Baeyer-Villiger mono-oxygenase to efficiently produce 2,2-disubstituted pyrrolidines with high yield and stereoselectivity.
- This study highlights an innovative mechanism for C-N bond formation that leverages the enzyme’s environment, combining molecular dynamics simulations and protein engineering to tackle complex synthesis challenges in a way that traditional chemical methods cannot.
Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions involve molecules operating from their ground states. Over the past 25 years, there has been an increased interest in enzymatic processes that utilize electronically excited states accessed through photoexcitation.
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