The effects of topical epinephrine on haemodynamics and markers of tissue perfusion in burned and non-burned patients requiring skin grafting.

Objective: To compare the systemic effects in burn and non-burn patients undergoing skin grafting with or without the use of topical epinephrine to control bleeding.

Background: The effects of topical epinephrine on haemodynamics and bleeding are principally documented with burn patients. No reports are available on the effects of topical epinephrine on non-burn patients especially on markers of tissue perfusion.

Glucose, lactate, and pyruvate response in an experimental model of microvascular flap ischemia and reperfusion: a microdialysis study.

Early diagnosis of postoperative perfusion failure is essential in microsurgical tissue transfer. In order to determine if microdialysis could be used in diagnosing flap ischemia, we tested this method in an experimental pig model. Sixty-six flaps (34 myocutaneous and 29 cutaneous) were created in 18 anesthetized pigs.