Publications by authors named "Ari Misael Martinez-Torres"
Article Synopsis
- Excitotoxicity involves harmful processes in the brain where NADPH oxidase-2 (NOX-2) produces reactive oxygen species (ROS), affecting crucial water channels like Aquaporin 4 (AQP4) and blood-brain barrier (BBB) integrity.
- The research explores the neuroprotective effects of cannabinoid receptor agonist WIN55,212-2 against glutamate-induced damage in the striatum of mice, focusing on the role of NOX-2.
- Results indicate that WIN55,212-2 reduces NOX-2-related ROS production, leading to less neuroinflammation, lower AQP4 expression, decreased edema, and improved BBB function during excitotoxic injury.
Brain edema is a critical complication arising from stroke and traumatic brain injury (TBI) with an important impact on patient recovery and can lead to long-term consequences. Therapeutic options to reduce edema progression are limited with variable patient outcomes. Aquaporin 4 (AQP4) is a water channel that allows bidirectional water diffusion across the astrocyte membrane and participates in the distinct phases of cerebral edema.
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