Publications by authors named "Arhant G"
Article Synopsis
- DNA genotyping from plasma for NSCLC has a high false-negative rate, showing a need for improved methods, especially for hard-to-reach tumors.
- This study compared DNA analysis from guide sheath flush fluid during r-EBUS bronchoscopy with plasma and tumor biopsies in 65 patients with peripheral NSCLC, finding that it allows for better mutation detection.
- The guide sheath flush method detected mutations in 61.8% of cases, significantly outperforming the 33% detection rate of plasma-based genotyping, suggesting it's a more sensitive approach for tumor DNA analysis.
Nonsense mutations are responsible for around 10% of cases of genetic diseases, including cystic fibrosis. 2,6-diaminopurine (DAP) has recently been shown to promote efficient readthrough of UGA premature stop codons. In this study, we show that DAP can correct a nonsense mutation in the Cftr gene in vivo in a new CF mouse model, in utero, and through breastfeeding, thanks, notably, to adequate pharmacokinetic properties.
View Article and Find Full Text PDFIntralesional rituximab treatment for atypical refractory granuloma faciale.
Ann Dermatol Venereol
December 2021