Publications by authors named "Argyri Mathioudaki"
Purpose: We aimed to characterize the RYGB-induced changes in the dynamics of brain glucose uptake. We addressed heterogeneity between brain regions during experimental normo- and hypoglycemia and explored associations with anthropometric and metabolic outcomes of RYGB.
Methods: Analyses of regional brain glucose uptake were performed on 9 individuals with obesity and no diabetes, investigated with combined brain F-FDG-PET and fMRI during hyperinsulinemic normo- and hypoglycemic clamp, one month before and four months after RYGB.
Objective: The objective was to study metabolic characteristics and transcriptome of renal sinus adipose tissue (RSAT) located around renal arteries and veins.
Methods: Adipose tissue biopsies from RSAT, omental (OAT), and subcutaneous (SAT) depots were obtained from healthy kidney donors (20 female, 20 male). Adipocyte glucose uptake rate and cell size were measured, and gene expression analyses using transcriptomics were performed.
The global prevalence of Type 2 Diabetes (T2D) poses significant public health challenges due to its associated severe complications. Insulin resistance is central to T2D pathophysiology, particularly affecting adipose tissue function. This cross-sectional observational study investigates metabolic alterations in subcutaneous adipose tissue (SAT) associated with T2D to identify potential therapeutic targets.
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- Catecholamine-stimulated lipolysis decreases with age, leading to increased fat accumulation and insulin resistance, linked to the function of OCT3, a transporter inhibited by estradiol (E2).
- The study involved analyzing subcutaneous adipose tissue (SAT) from women of varying ages and diabetes statuses to measure OCT3 mRNA levels and their correlation to insulin resistance.
- Results showed that OCT3 mRNA and protein levels rise with age and postmenopause, but decrease with E2 treatment, suggesting that higher OCT3 levels may impair lipolysis and contribute to insulin resistance in older women.
Objectives: To further elucidate the role of the MHC in ankylosing spondylitis by typing 17 genes, searching for independent associations and assessing the impact of sex on this male biased disease.
Methods: High-confidence two-field resolution genotyping was performed on 310 cases and 2196 controls using an concordance method. Protein-coding variants were called from next-generation sequencing reads using up to four software programs and the consensus result recorded.
Breast cancer (BC) is a genetically heterogeneous disease with high prevalence in Northern Europe. However, there has been no detailed investigation into the Scandinavian somatic landscape. Here, in a homogeneous Swedish cohort, we describe the somatic events underlying BC, leveraging a targeted next-generation sequencing approach.
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- Autoimmune Addison's disease (AAD) is the main cause of primary adrenal failure, and while it has high heritability, its rarity has limited genetic research to candidate-gene studies.
- A comprehensive study investigated risk loci and over 1800 candidate genes in 479 AAD patients and 2394 controls, confirming some previous risk variants while disproving others.
- The research identified a new risk locus in the autoimmune regulator gene (AIRE) and highlighted that the known risk loci only account for about 7% of the genetic risk for AAD in the population studied.