Publications by authors named "Argelia Calvillo-Robledo"
Animal models, mainly murine, stay as a fundamental resource in diverse research pursuits, notably contributing to significant strides in discovering novel treatments for therapeutic applications. Preclinical assays must consider the existence of self-recovery mechanisms in the murine species to achieve a well-designed control group. This study focuses on unveiling the innate rapid regenerative capacity of rat liver by utilizing the thioacetamide-induced sub-chronic liver injury model.
View Article and Find Full Text PDFArginine vasopressin hormone receptor antagonists in experimental autoimmune encephalomyelitis rodent models: A new approach for human multiple sclerosis treatment.
Front Neurosci
March 2023
Article Synopsis
- Multiple sclerosis (MS) is a complex, chronic disease affecting the central nervous system, linked to immune system dysfunction and barrier breakdown.
- The growing incidence of MS and the side effects of current treatments highlight the need for new therapies, leading to research utilizing animal models like experimental autoimmune encephalomyelitis (EAE) to better understand the disease.
- This review explores conivaptan, an AVP receptor blocker, as a promising treatment option that could effectively modulate immune responses in MS with fewer side effects compared to traditional therapies.
GPR55 is an orphan receptor whose endogenous agonists include lysophosphatidylinositol (LPI) and N‑acetylethanolamides (NAEs), such as palmitoylethanolamide (PEA) and anandamide. Furthermore, its physiology in the central nervous system involves motor coordination, procedural and spatial memory, pain, and anxiety, among others. Recent reports indicate that systemic injections of O‑1602 (a GPR55 and GPR18 agonist) blocked the reinforcing effects of morphine and nicotine in the conditioned place preference (CPP) paradigm, suggesting a possible participation of peripheral and/or central GPR55/GPR18 in brain reward/anti‑reward systems.
View Article and Find Full Text PDFArticle Synopsis
- GPR55 is an orphan G protein-coupled receptor linked to various health issues like metabolic dysfunction and cancer, drawing significant research interest.
- Cannabinoids, both natural and synthetic, can influence GPR55 activity, suggesting it plays a role in the endocannabinoid system.
- The LPI/GPR55 pathway is being explored as a potential cancer biomarker and therapeutic target, with its involvement in cancer progression and correlation with tumor aggressiveness being key areas of investigation.
GPR55 is a receptor expressed in several central nervous system areas, including the periaqueductal gray (PAG). Current knowledge of GPR55 physiology in PAG only covers pain integration, but it is involved in other actions such as anxiety, panic, motivated behaviors, and alcohol intake. In the present study, juvenile male Wistar rats were unexposed (alcohol-naïve group; A-naïve) or exposed to alcohol for 5 weeks (alcohol-pre-exposed group; A-pre-exposed).
View Article and Find Full Text PDFBackground: Ovarian cancer is usually diagnosed at an advanced stage due to its early asymptomatic course and late-stage non-specific symptoms. This highlights the importance of researching the molecular mechanisms involved in ovarian carcinogenesis as well as the discovery of novel prognostic markers that could help improve the survival outcome of patients. The aim of this study was to evaluate the expression of the steroid sulfatase (STS) in 154 samples of primary ovarian tumors.
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