99mTc-D(RGD): molecular imaging probe for diagnosis of αvβ3-positive tumors.

Objective: Arginine-glycine-aspartic acid (RGD) peptide with its specific binding affinity to integrin αvβ3, is widely investigated for the development of molecular imaging probes for diagnosis of αvβ3-positive tumors. The aim of this work was to evaluate the ability of Tc- HYNIC-D(RGD), a novel retro-inverso peptidomimetic derivative for U87MG tumor (αvβ3-positive) imaging.

Methods: HYNIC-D(RGD) labeled with Tc using tricine/EDDA as an exchange coligands.