Preparation and characterization of Pullulan-based nanocomposite scaffold incorporating Ag-Silica Janus particles for bone tissue engineering.

A nanocomposite bone scaffold was fabricated from pullulan, a natural extracellular polysaccharide. Pullulan (PULL) was blended with polyvinylpyrrolidone (PVP), and a nano-platform with ball-stick morphology, Ag-Silica Janus particles (Ag-Silica JPs), which were utilized to fabricate nanocomposite scaffold with enhanced mechanical and biological properties. The Ag-Silica JPs were synthesized via a one-step sol-gel method and used to obtain synergistic properties of silver and silica's antibacterial and bioactive effects, respectively.

Leuprolide Acetate Release Study from γ-Irradiated PLGA-based In Situ Forming System.

Background: It is well known that the properties of polymers can be altered by exposure to γ- ray. γ-irradiation has been used as a sterilization method for polymeric drug delivery devices, and its drug release profile must not be significantly changed. In this study, the effect of γ-irradiation on the release profile of leuprolide acetate from PLGA-based in situ forming system was investigated.