Publications by authors named "Arezki K Boukerma"
Article Synopsis
- GHB is produced naturally from GABA or can be obtained from substances like 1,4-butanediol and GBL, which are quickly converted to GHB in the body.
- When ingested, GHB has a rapid absorption rate and its effects vary based on dosage, often leading to neurological disorders and potential withdrawal symptoms with long-term use.
- While GHB is regulated internationally due to its association with abuse and drug-facilitated crimes, substances like GBL and 1,4-BD are not as strictly controlled, necessitating careful monitoring to prevent misuse and related health risks.
Purpose: This prospective pharmacokinetic (PK) ancillary study of the TEXCAN phase II GERCOR trial of patients with chemorefractory metastatic colorectal cancer and treated with regorafenib (REGO) investigated correlations between overall survival (OS) and concentrations (C) of REGO and its active metabolites, M-2 and M-5.
Methods: 55 patients received REGO 160 mg/day for 21 days of a 28-day cycle (NCT02699073). REGO, M-2, M-5 were measured by liquid chromatography-mass spectrometry assay on day 15 of cycle 1 (C1) and 2 (C2).