The 4Hz mechanical vibration-activated Na/Ca exchange as a quantum-sensitive novel target for pain therapy.

The activation of Na/Ca exchange in reverse (R) mode leading to neuronal swelling and muscle contraction has been suggested as a mechanism for generation of pain signals. However, the activation of R Na/Ca exchange, having higher rate than R Na/Ca exchange, brings to depression of pain sensation, the mechanism of which is not clear. The previous data that the 4 Hz mechanical vibration (MV) has pain-relieving effects by activation of cGMP-dependent Na/Ca exchange in forward (F) mode, which leads to muscle hydration and neuronal dehydration, as in case of R Na/Ca exchange activation, allow us to suggest that the comparative study of the effects of 4 Hz MV and R Na/Ca exchange on thermal pain thresholds, tissue hydrations in different experimental conductions will make it possible to evaluate the mechanisms of R Na/Ca exchange-induced inhibition of pain sensation.