Expression of thyrotropin-releasing hormone by human melanoma and nevi.

Purpose: Thyrotropin-releasing hormone (TRH) is a tripeptide hormone produced by the hypothalamus in response to hypothyroidism. RNA transcripts for the TRH prohormone have recently been described in melanoma cell lines. To expand these findings, we have examined cultured melanoma cells and melanocytes, human melanoma tumors, and nevi for the expression of TRH.

Scleritis as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation.

Purpose: To describe a case of scleritis with choroidal detachment as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation.

Design: Interventional case report.

Methods: Review of clinical records.