Application of iron oxide nanoparticles to control the release of minocycline for the treatment of glioblastoma.

The utilization of iron oxide nanoparticles (FeO NPs) to control minocycline release rates from poly(lactic-co-glycolic acid) scaffolds fabricated from an easy/economical technique is presented. A larger change in temperature and amount of minocycline released was observed for scaffolds with higher amounts of FeO NPs, demonstrating that nanoparticle concentration can control heat generation and minocycline release. Temperatures near a polymer's glass transition temperature can result in the polymer's chain becoming more mobile and thus increasing drug diffusion out of the scaffold.