Publications by authors named "Arefeh Vakilian"
Article Synopsis
- The study examined how an extract from the plant L. (OB) affects learning and memory in older rats, comparing 2-month-old control rats with 2-year-old aged rats.
- Aged rats showed worse memory performance in tasks like the Morris water maze and passive avoidance tests, along with increased levels of inflammatory markers and oxidative stress.
- The administration of OB extract improved the cognitive deficits and helped protect brain tissues from damage caused by aging.
Objective: Adolescence is a crucial time for brain maturation. We investigated the protective effects of metformin (Met) on behavioral changes, oxidative stress, tumor necrosis factor alpha (TNF-α) and nitrite in adulthood induced by ethanol (Eth) consumption during adolescent to adult period of rats.
Materials And Methods: The adolescence male rats (21 days old) were treated as: 1) Control, 2) Eth (Eth in drinking water (20 %)), 3-5) Eth-Met50, 100 and 150 mg/kg (Eth in drinking water and Met (50, 100, or 150 mg/kg).