Clinical and morphological characteristics, diagnostic criteria, and outcomes of surgical treatment of TSH-secreting pituitary adenomas.

Unlabelled: Thyrotropinomas (TSH-secreting tumors) are a rare type of pituitary adenomas, which account for about 0.5-2.0% of all pituitary tumors.

The rate of hyponatremia in neurosurgical patients (comparison between the data from the Burdenko Neurosurgical Instutite and the literature) and recommendations for the diagnosis and treatment.

Unlabelled: Hyponatremia is a relatively frequent and serious complication in patients with various neurosurgical pathologies.

Objective: This study is aimed at assessing the incidence of hyponatremia in neurosurgical patients depending on the pathology.

Material And Methods: This paper presents a retrospective analysis 39 479 cases of patients operated on at the Burdenko Neurosurgical Institute from 2008 to 2014.

Endovascular treatment of large and giant intracranial aneurysms using flow-diverting stents.

Objective: The objective was to evaluate the efficacy of treatment of patients with large and giant cerebral arterial aneurysms using flow-diverting stents (FDSs).

Material And Methods: The treatment outcomes of 210 patients with large and giant intracranial aneurysms were analyzed. The study included patients with both asymptomatic and symptomatic aneurysms (manifested by SAH or pseudotumorous course).

[Requirements for analytical quality: use of the concept of biological variation].

By using a clinical biochemistry laboratory as an example, the authors show how the analytical quality system practically operates. The advantages of using a three-level model for analytical quality requirements on the basis of biological variations in analytes are discussed. Only does the use of a few normative documents present a possibility of creating an adequate quality system in a specific laboratory.

[Testing the acceptability of applied reference intervals, by using serum creatinine as an example].

Unfortunately, the international standard ISO 15189:2003 does not give clear guidelines for the choice, development, and testing the acceptability of reference intervals. The so-called normalization of the frequency distribution of serum creatinine concentrations was carried out in the population of outpatients above 18 years of age. Creatinine concentrations were measured, using 5 analytical systems: Abbott Architect (n=9054), Roche Modular (n = 22,947), Roche Integra 400 (n=2748), Roche Integra 700 (n=8350), and Roche Hitachi (n = 20,196).

[Physiological and biochemical characteristics and capacity for polyhydroxyalkanoates synthesis in a glucose-utilizing strain of hydrogen-oxidizing bacteria, Ralstonia eutropha B8562].

The physiological, biochemical, genetic, and cultural characteristics of the glucose-utilizing mutant strain Ralstonia eutropha B8562 were investigated in comparison with the parent strain R. eutropha B5786. The morphological, cultural, and biochemical characteristics of strain R.

[Lipid peroxidation in the cyst fluid of craniopharyngiomas].

Comparing of the craniopharyngiomas cyst fluid, collected during the surgery, with blood plasma revealed significantly enhanced lipid peroxidation and lactate accumulation in tumour cysts contents. These processes were usually more prominent in endosuprasellar than in suprasellar craniopharyngiomas. The maximum of free radical formation in conjunction with the lowest level of malondialdehyde (MDA) was observed in primary tumours with relatively high proliferation rate.

[Computer method for evaluating disorders in sense of color].

A new method for evaluating disorders in the sense of color has been developed and offered for practice. A total of 340 patients with diseases of the retina and optic nerve and 80 normal subjects were examined. The results indicate that different conditions of examination, selection of combination by the color, brightness, and deepness of the stimulus and background allow detection of decreased sensitivity of one, two, or three color perceptors (disorders in sense of color--color blindness) and permit a quantitative evaluation of functional disorders in the color channels of visual system.

[The role of biochemical processes in the pathogenesis of complicated hydrocephalus in children].

Spinal fluid radical formation levels, malonic dialdehyde concentrations, and intrinsic antioxidative activity were studied in 84 patients with hydrocephalus. The findings suggest that there is a considerable activation of free radical reactions and lipid peroxidation, as well as a reduction in antioxidative activity. These changes were most drastically profound in children with inflammation-complicated hydrocephalus with spinal fluid hemorrhagic changes in particular.

[Cerebral hemodynamics and metabolism in the acute stage of cerebral aneurysm rupture].

The relationship between lipid peroxidation products and the severity of arterial spasm was studied in 86 patients. For this, the level of radical production, the content of the end lipid peroxidation product malonic dialdehyde and the overall antioxidative activity of lumbar cerebrospinal fluid were determined during 24-hour Doppler monitoring of blood flow in the middle cerebral and internal carotid arteries. Following subarachnoidal hemorrhage, the activation of lipid peroxidation processes was shown to correlate with the severity of arterial spasm and it is likely to contribute to the development of late ischemias.

[Study of free radical oxidation of lipids in cerebrospinal fluid of hydrocephalic children].

The levels of free radical production, malondialdehyde concentration and antioxidant activity were estimated in ventricular liquor of the infants with primary hydrocephalus. It was shown that even in the case of uncomplicated hydrocephalus significant disorders in brain metabolism took place. In the patients with inflammatory or hemorrhagic complications the levels of malondialdehyde and free radicals were markedly increased as compared to the infants with "pure" hydrocephalus.

[Endogenous intoxication and its treatment with sodium hypochlorite in neurosurgical patients].

Blood plasma levels of medium-mass molecules (MMM), antioxidant activity (AOA), and malonic dialdehyde (MDA) were measured in 51 neurosurgical patients before and directly and 24 h after intravenous drip infusion of sodium hypochlorite (SHC) solution. Preliminary in vitro studies showed the most expressed drop of initially high MDA and MMM levels to be associated with an increase of AOA. It was observed at SHC concentration of 0.

[A new method of assessing contrast sensitivity in patients with eye diseases].

A new method for examining spatial contrast sensitivity (SCS) is described, making use of the display of an IBM-compatible computer, on which sinusoidal patterns are presented: achromatic and chromatic red, green, blue against the black background at a frequency of 0.5 to 22 cycles/degree. In health similarity of curves to the achromatic and chromatic patterns was observed, with the maximal sensitivity at spatial frequencies from 2 to 8 cycles/degree and a reduction at low and high spatial frequencies.

[Reserves in decreasing maternal mortality due to obstetrical hemorrhages].

Analysis of 542 lethal cases at pregnancy terms 28 weeks and more, of parturients and puerperae in Russia over 1987-1991 has shown that obstetrical bleedings were responsible for 42.2% of deaths, being the most frequent causes of lethal outcomes. Analysis of records documenting 283 lethal cases has shown a high incidence of somatic (90.