Publications by authors named "Areej Bawaane"
This study aim to examine the hypothesis that repetitive painful stimuli during infancy will alter pain sensitivity and impair learning and memory during adulthood and that saccharin will prevent this through its analgesic effect. Naltrexone is used to examine if saccharin effect is mediated via the endogenous opioid system. Pain in rat pups was induced via needle pricks of the paws on day 1 of their birth (P0).
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- * Sucrose is effective in reducing pain from single painful events in newborns, but its exact pain-relieving mechanism remains unclear; the study examined the role of the opioid system through the use of naltrexone.
- * Findings reveal that combining naltrexone with sucrose not only alleviates pain sensitivity but also prevents impairment in long-term memory caused by neonatal pain, likely by normalizing levels of brain-derived neurotrophic factor (BDNF) and increasing β-endorphin levels in the brain.