Publications by authors named "Ardita Koteci"
Interstitial lung disease (ILD) is a collective term representing a diverse group of pulmonary fibrotic and inflammatory conditions. Due to the diversity of ILD conditions, paucity of guidance and updates to diagnostic criteria over time, it has been challenging to precisely determine ILD incidence and prevalence. This systematic review provides a synthesis of published data at a global level and highlights gaps in the current knowledge base.
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- Cardiovascular disease, particularly left-sided heart failure (HF), is a significant concern for patients with idiopathic pulmonary fibrosis (IPF) in England, with its prevalence showing a decline from 33.4% in 2010 to 20.9% in 2019.
- The study analyzed data from over 25,000 IPF patients, revealing that while the incidence rates of HF remained stable initially, they dropped between 2017 and 2019, especially among older men.
- Comorbid left-sided HF notably increased the risk of mortality in patients with IPF, highlighting the serious health implications of this dual condition compared to patients with chronic obstructive pulmonary disease (COPD).
Objectives: To describe the rates for consulting a general practitioner (GP) for sequelae after acute covid-19 in patients admitted to hospital with covid-19 and those managed in the community, and to determine how the rates change over time for patients in the community and after vaccination for covid-19.
Design: Population based study.
Setting: 1392 general practices in England contributing to the Clinical Practice Research Datalink Aurum database.
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical genetic approaches to probe the function of PM PI4P, most of which was not required for the synthesis or functions of PI(4,5)P(2). However, depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel.
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