[HEART RHYTHM VARIABILITY ANALYSIS AND ASSESSMENT OF THE SPINAL PAIN SYNDROME DURING DRY IMMERSION].

The spinal pain syndrome appears in cosmonauts on both short and long-duration missions. This untoward factor may affect body systems functioning and complicate the successful accomplishment of space mission. Purpose of the investigation was to examine the lumbar spine and to elucidate whether its condition relates to the spinal pain development and changes in heart rate variability (HRV) in the microgravity environment.

[Prognostication of the probability of ischemic stroke].

The study included 405 patients with ischemic stroke and 35 ones with transitory ischemic attack. Predictors of stroke are considered and approaches to its prognostication proposed The results can be used to distinguish patients in need of preventive therapy of ischemic stroke.

[Clinico-diagnostic and expert characteristics of noncoronary cardiac rhythm disorders in state aviation pilots].

Structure and prevalence of various forms of noncoronary heart diseases (NCHD) and cardiac rhythm disorders (CRD) in state aviation pilots, as well as rates of ensuing grounding were studied. The total of 220 NCHD and 100 essentially healthy pilots were examined. Cardiovascular clinical and functional investigations consisted of physical examination, ECG, dispersion mapping (DM ECG), provocative tests and other techniques used for pilots' certification.

[Electrophysiological characteristics of heart rate regulationin patients with the phenomenon and syndrome of Wolff-Parkinson-White's].

The paper presents the results of electrocardiography, echocardiography, heart rate variability, nonlinear dynamicsin patients with the phenomenon and syndrome of Wolff-Parkinson-White's (WPW). 54 patients whom we divided into 3 groups were included in research: group of patients with WPW a phenomenon, with WPW a syndrome and group of healthy. We proved a role of the main pathophysiological mechanisms in formation of pathology of heart at WPW a syndrome with use of mathematical models.

[Prognosis of the immediate period of an ischemic stroke].

We investigated 342 patients with clinical outcome of a disease and 61 died patients with acute disease. With the help of the method of representative sample of patients with an ischemic stroke the clinical picture and data about tool methods of research are investigated. We received solving rules of forecasting of favorable and adverse outcomes ischemic stroke with use of the discriminative analysis.

[Evaluation of the radiofrequency ablation effectiveness in patients with the Wolff-Parkinson-White syndrome].

A one-year prospective study involved 22 patients with the Wolff-Parkinson-White syndrome (WPW) and 20 healthy people. Means age of patients was 34.3 +/- 16.

[Parameters of central hemodynamics in patients with typical atrial flutter before and after radiofrequency catheter ablation].

We present here results of dynamic assessment of morphofunctional state of the myocardium by the method of transthoracic echocardiography (EchoCG) in patients with paroxysmal and chronic forms of typical atrial flutter (AF) before and during one year after radiofrequency catheter ablation (RFA) of cavo-tricuspid isthmus, and comparison of them with analogous parameters in a group of healthy volunteers. Eighty six patients participated in the study. Group 1 comprised 48 patients suffering from paroxysmal form of typical AF including 42 (87.

[Nonischemic ventricular arrhythmias: classification, clinical manifestations, diagnosis, and treatment].

Clinico-electrocardiographical and electrophysiological features of noncoronarygenic ventricular arrhythmias are presented. Characteristics of localization of arrhythmogenic focus in various parts of left and right ventricular myocardium, in interventricular septum, and in immediate vicinity of each of 4 valves are discussed. Spectrum of necessary diagnostic measures is delineated, and assessment of efficacy of drug therapy is given.

[First in Russia experience of radiofrequency ablation with the help of robotic system of magnetic navigation on the occasion of heart rhythm disturbances].

We present first in Russia experience of interventional treatment of 15 patients (11 men, 4 women, mean age 34.2 +/- 13.9 years) in whom operations of endocardial electrophysiological study (endoEPS) and radiofrequency ablation (RFA) with the help of robotic system of magnetic navigation were carried out because of various disturbances of cardiac rhythm.

[Possibilities of early surgical correction of postinfarction remodeling of the heart].

Postinfarction remodeling of the heart (PIRH) has unfavorable prognostic value because is associated with elevated risk of fatal arrhythmias, emergence and progression of heart failure. Reversibility of PIRH in early period after myocardial infarction causes interest. We followed dynamics of echocardiographical parameters in a patient who had undergone myocardial infarction with subsequent aorto-coronary bypass operation.

[The clinical picture and outcomes of myocardial infarction which developed in a multifield hospital].

The aim of the investigation was to study most frequent clinical variants of myocardial infarction (MI) onset at a multifield hospital, as well as some features of its course and outcomes in patients undergoing treatment at different departments. The study found that the onset of intrahospital MI was often atypical, and that atypical onset was most frequent in cases of myocardial necrosis in patients undergoing treatment in surgical and therapeutic departments. The clinical picture, ECG data, and outcomes were analyzed in patients with MI whose onset took place at different hospital departments.

[Long-term results of low-speed irrigated radiofrequency catheter ablation of atrial flutter].

The authors studied long-term results of low-speed (10 ml/min) irrigated radiofrequency catheter ablation (RFA) of the lower isthmus (LI) in patients with typical atrial flutter (AF). This treatment was based upon combined use of local and indirect criteria of the block of isthmus conduction. The influence of RFA LI on quality of life (QL), echocardiographic parameters and cardiac rhythm variability (CRV) was studied.

[The main reasons for late diagnosis and errors in the early period of treatment of intrahospital myocardial infarction in a general hospital].

The purpose of the study was to investigate the reasons for late diagnosis and late transfer of hospitalized patients with myocardial infarction (MI) to a specialized cardiological department. The study shows that the main reasons are an atypical clinical picture of MI and a low "infarct alert" of doctors of different specialties. The authors analyzed the fullness of urgent medical aid and the beginning of treatment in cases of intrahospital MI in patients being treated in different hospital departments.

[A case of primary amyloidosis].

Diagnostics of primary (AL) amyloidosis is difficult enough; treatment of this disease in not less difficult or more adequate. Because of similarity of the pathogenesis of AL-amyloidosis and that of multiple myeloma, similar therapeutic regimens, directed towards depression of plasma cell dyscrasia, are used in both cases: administration of melphalan in various doses together with prednisolone, administration of vincristine, adriablastine and dexamethasone, as well as high-dose chemotherapy with melphalan and autologic stem cell transplantation. This therapeutic approach makes it possible to reach clinico-laboratory remission and prolong the life of patients with AL-amyloidosis.

[The cell immunity parameters in patients with acute coronary syndrome].

The subjects of the study were 75 patients with instable angina (IA) and 16 patients with chronic coronary heart disease (CHD) following transcutaneous transluminal balloon angioplasty (TTBA). Their examination included the evaluation of the changes of some cell immunity parameters, such as the levels of interleukins IL-1, IL-6, and IL-10, tumor necrosis factor alpha (TNFalpha), and serum neopterin (NEOP), the measurement of C-reactive protein level, the detection of certain viral agents in blood (herpes simplex virus (HSV), cytomegalovirus, Chlamydia pneuoniae) using polymerase chain reaction (PCR), The study revealed such signs of cell immunity disbalance as the pronounced activation of pro-inflammatory factors (IL-6, TNFalpha, and serum NEOP). Along with no changes of the activity of anti-inflammatory factors (IL-10), the research revealed the similar direction of immune shifts in IA patients and CHD patients who had no clinical signs of exacerbation and had undergone TTBA.

[The predictors of ischemic stroke in cerebral atherosclerosis and ischemic heart disease].

The complex medical examination was performed in 145 patients admitted to the neurological department with initial diagnosis: "ischemic stroke". We compared anamnesis, clinical symptoms, laboratory and instrumental findings in the patients with verified ischemic stroke and in those without stroke. The significant clinical predictors of ischemic stroke were the following: arterial hypertension (> 165/ 95 mm Hg) age 64 years and older, circulatory insufficiency, diabetes, atrial fibrillation, lower extremity obliterating atherosclerosis, pneumosclerosis and pulmonary emphizema.