Precocious puberty and large multicystic ovaries in young girls with primary hypothyroidism.

Objective: To describe 2 cases of primary hypothyroidism, precocious puberty, large multicystic ovaries, possible diagnostic dilemma, unilateral oophorectomies, and subsequent response to levothyroxine replacement therapy.

Methods: We present the clinical, biochemical, radiologic, and histopathologic findings in 2 patients with rare cases of Van Wyk-Grumbach syndrome and megaovaries, who underwent unilateral oophorectomy.

Results: Two patients, an 8-year-old girl and a 3-year-old girl (cases 1 and 2, respectively), were referred to our center.