Intradural calcifying fibroblastic proliferation associated with a nerve root: a reactive process mimicking a nerve sheath tumor.

Study Design: Case Report.

Objective: To share our experience about the unique histological appearances of a calcified intradural, extramedullary lesion involving a nerve root.

Summary Of Background Data: A 53-year-old man presented with a long history of low back pain and a few months of occasional left groin pain with no neurological deficit.

p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma.

Aberrant cytoplasmic sequestration has been reported as an alternative mechanism of p53 inactivation to mutation in neuroblastoma. We hypothesized that p53 localization and function in neuroblastoma is related to differentiation status. Eighty-two untreated and 24 paired pre and post-chemotherapy neuroblastomas were studied by immunocytochemistry for p53, p21(WAF1), BAX, Bcl2 and Ki67.