Evolution in regression patterns following chemoreduction for retinoblastoma.

Objective: To evaluate the change in regression pattern following chemoreduction and tumor consolidation therapy (thermotherapy or cryotherapy) for retinoblastoma

Methods: Retrospective medical record analysis was completed for 557 retinoblastomas (239 eyes of 157 patients) that were treated with chemoreduction and showed regression to 1 of 5 patterns (type 0, no visible remnant; type 1, completely calcified remnant; type 2, completely noncalcified remnant; type 3, partially calcified remnant; and type 4, atrophic chorioretinal flat scar). Evolution of these regression patterns was observed over time.

Results: Immediately following 6 cycles of chemoreduction, types 0 (2%), 1 (30%), 2 (3%), 3 (33%), and 4 (32%) regression patterns were found.

Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes.

Objective: To determine the rate of metastasis of uveal melanoma on the basis of tumor thickness in millimeters.

Methods: Retrospective medical record review.

Results: The mean (median) patient age was 58 (59) years.

Necrotic choroidal melanoma with scleritis and choroidal effusion.

Purpose: To report a case of a choroidal melanoma that presented with painful scleritis and choroidal effusion.

Methods: Interventional case report with cytopathologic correlation.

Results: A 78-year-old otherwise healthy woman presented with sudden, severe painful ocular inflammation and marked injection of the right eye over a 3-day period, consistent with scleritis.

Chemoreduction for group E retinoblastoma: comparison of chemoreduction alone versus chemoreduction plus low-dose external radiotherapy in 76 eyes.

Purpose: To evaluate chemoreduction (CRD) for group E retinoblastoma.

Design: Retrospective, comparative case series.

Participants: Seventy-six eyes of 56 patients with group E retinoblastoma were treated with CRD alone or CRD plus low-dose prophylactic external beam radiotherapy (CRD+P-EBR).

Combined hamartoma of the retina and retinal pigment epithelium in 77 consecutive patients visual outcome based on macular versus extramacular tumor location.

Purpose: To evaluate visual outcome of eyes with combined hamartoma of the retina and retinal pigment epithelium (RPE).

Design: Noncomparative case series.

Participants: Seventy-nine eyes of 77 patients.

Clinical spectrum of diffuse infiltrating retinoblastoma in 34 consecutive eyes.

Purpose: To evaluate the clinical features and management of diffuse infiltrating retinoblastoma.

Design: Retrospective case series.

Participants: Thirty-four eyes in 32 patients.

Primary acquired melanosis of the conjunctiva: experience with 311 eyes.

Purpose: To evaluate clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma.

Methods: Retrospective chart review and Kaplan-Meier estimates of times to PAM enlargement, recurrence, and transformation into melanoma.

Main Outcome Measures: PAM enlargement, recurrence, and transformation into melanoma.

Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture.

Purpose: To evaluate the clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma.

Design: Noncomparative case series.

Participants: Three hundred eleven eyes with conjunctival PAM without melanoma at initial examination from a single-center tertiary referral center.

Iris cavernous hemangioma associated with multiple cavernous hemangiomas in the kidney, brain, and skin.

Purpose: To document the relationship of iris cavernous hemangiomas with multiorgan hemangiomas in a child.

Methods: A 7-year-old girl with kidney hemangiomas, brain hemangiomas, and skin hemangiomas developed blurred vision and darkening of the right iris. She had undergone 6 previous brain surgeries and multiple revisions of a ventriculoperitoneal shunt for hydrocephalus beginning at age 3 months.