Feasibility of aligning creatine kinase MB activity and mass data in multicentre trials using generalized additive modelling.

Objectives: Elevated serum creatine kinase isoenzyme MB (CK-MB) levels indicate myocardial ischaemia and periprocedural myocardial injury during treatment of heart diseases. We established a method to predict CK-MB mass from activity data based on a prospective pilot study in order to simplify multicentre trials.

Methods: 38 elective cardiac surgery patients without acute myocardial ischaemia and terminal renal failure were recruited.